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Activin A Receptor, Type IIB Proteine (ACVR2B)

Activin A Receptor, Type IIB Proteine (ACVR2B)
Auf finden Sie aktuell 33 Activin A Receptor, Type IIB (ACVR2B) Proteine von 11 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Activin A Receptor, Type IIB Antikörper (122) und Activin A Receptor, Type IIB Kits (2) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 175 Activin A Receptor, Type IIB Produkte verfügbar.
ActR-IIB, actr2b, actrIIb, ACVR2B, HTX4, wu:fj97d11, XAR1
alle Proteine anzeigen Gen GeneID UniProt
ACVR2B 93 Q13705
ACVR2B 25366 P38445
ACVR2B 11481 P27040

Weitere Synonyme anzeigen

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Am meisten referenzierte Activin A Receptor, Type IIB Proteine

  1. Cynomolgus ACVR2B Protein expressed in Human Cells - ABIN2009777 : Hildén, Tuuri, Erämaa, Ritvos: Expression of type II activin receptor genes during differentiation of human K562 cells and cDNA cloning of the human type IIB activin receptor. in Blood 1994 (PubMed)
    Zeige alle 4 Referenzen für ABIN2009777

  2. Human ACVR2B Protein expressed in Human Cells - ABIN2002394 : Persson, Souchelnytskyi, Franzén, Miyazono, ten Dijke, Heldin: Transforming growth factor (TGF-beta)-specific signaling by chimeric TGF-beta type II receptor with intracellular domain of activin type IIB receptor. in The Journal of biological chemistry 1997 (PubMed)
    Zeige alle 3 Referenzen für ABIN2002394

  3. Mouse (Murine) ACVR2B Protein expressed in Human Cells - ABIN2007451 : Matzuk, Bradley: Structure of the mouse activin receptor type II gene. in Biochemical and biophysical research communications 1992 (PubMed)
    Zeige alle 3 Referenzen für ABIN2007451

  4. Human ACVR2B Protein expressed in HEK-293 Cells - ABIN2180560 : Attisano, Wrana, Montalvo, Massagué: Activation of signalling by the activin receptor complex. in Molecular and cellular biology 1996 (PubMed)

Weitere Proteine zu Activin A Receptor, Type IIB Interaktionspartnern

Horse (Equine) Activin A Receptor, Type IIB (ACVR2B) Interaktionspartner

  1. ActRIIB mRNA but not protein was decreased in skeletal muscle of obese compared with lean animals.

Human Activin A Receptor, Type IIB (ACVR2B) Interaktionspartner

  1. TGF-beta (zeige TGFB1 Proteine) receptor mediated telomerase inhibition, telomere shortening and breast cancer cell senescence.(

  2. ActR-IIB is expressed in male germ cells and Sertoli cells.

  3. Activin A (zeige INHBA Proteine) inhibited signaling by BMP-6 (zeige BMP6 Proteine) and BMP-9 (zeige GDF2 Proteine) by competing for type 2 receptors ACVR2A (zeige ACVR2A Proteine) and ACVR2B.

  4. We found that the AAAAA, AGGAG, and AGGGA haplotypes in ACVR2B were associated with susceptibility to Premature Ovarian Failure when they also had at least one CATAG haplotype in ADAMTS19.

  5. miR (zeige MLXIP Proteine)-21 interacts directly with the 3'-untranslated region of ACVR2B mRNA. Mechanical stretch suppressed ACVR2B protein levels in periodontal ligament stem cells. Gain- and loss of function of ACVR2B mediated the osteogenic differentiation of PDLSCs.

  6. Adenomyotic tissues express high levels of myostatin, follistatin, and activin type II receptors.

  7. Activin type IIB receptors are clearly demonstrable throughout the adult human hypothalamus and basal forebrain.

  8. After eccentric exercise, postmenopausal women not using hormone therapy (HT) expressed lower levels of ActRIIb while postmenopausal women using HT showed a heightened response.

  9. The interaction between all five miRNAs and ACVR2B was verified by an in vitro assay.

  10. Mutations in Activin A Receptor Type IIB were identified in 4 of the 47 patients (8.5%) with heterotaxy syndrome. Our results expand the mutation spectrum of monogenic heterotaxy syndrome with associated cardiac anomalies.

Zebrafish Activin A Receptor, Type IIB (ACVR2B) Interaktionspartner

  1. Roles in hindbrain and neural crest cell (NCC) patterning, in NCC derived pharyngeal arch cartilage and joint formation, and in tooth development.

Mouse (Murine) Activin A Receptor, Type IIB (ACVR2B) Interaktionspartner

  1. Differential muscle hypertrophy is associated with satellite cell numbers and Akt (zeige AKT1 Proteine) pathway activation following activin type IIB receptor inhibition in Mtm1 (zeige MTM1 Proteine)

  2. ActRIIB inhibition enhanced energy expenditure only at ambient temperature or in the cold, where nonshivering thermogenesis is minimal, suggesting that brown fat activation plays a prominent role in the metabolic actions of ActRIIB inhibition.

  3. findings best fit a model in which BMP3 (zeige BMP3 Proteine), produced by mature bone cells, acts to reduce BMP signaling through Acvr2b in skeletal progenitor cells, limiting their differentiation to mature osteoblasts

  4. Functional redundancy in osteoblast differentiation is observed between bone morphogenetic protein receptor BMPR-II (zeige BMPR2 Proteine) and ActR-IIB.

  5. Inhibition of activin receptor type IIB increases strength and lifespan in myotubularin (zeige MTM1 Proteine)-deficient mice.

  6. Akt (zeige AKT1 Proteine) isoforms are not essential for for the ability of ActRIIB inhibition to regulate muscle size and function .

  7. ActRIIB plays a role in the specification of left-sidedness in developing mice

  8. Activin type IIB(ActRIIB) and its subfamily receptor, Activin type IIA (ActRIIA (zeige ACVR2A Proteine)), cooperatively mediate the Gdf11 (zeige GDF11 Proteine) signal in patterning the axial vertebrae

  9. ActRIIB is expressed in the early development of thymocytes.

  10. genetic evidence strongly suggested that ActRIIB and Smad2 (zeige SMAD2 Proteine) function in the same signaling pathway to regulate axial patterning and pancreas islet formation by means of a threshold mechanism.

Activin A Receptor, Type IIB (ACVR2B) Protein Überblick

Protein Überblick

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling\; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.

Alternative names and synonyms associated with Activin A Receptor, Type IIB (ACVR2B)

  • activin A receptor, type IIB (ACVR2B)
  • activin A receptor, type IIB (acvr2b)
  • activin A receptor, type IIB (Acvr2b)
  • activin receptor IIb (acvr2b)
  • activin receptor IIB (Acvr2b)
  • ActR-IIB Protein
  • actr2b Protein
  • actrIIb Protein
  • ACVR2B Protein
  • HTX4 Protein
  • wu:fj97d11 Protein
  • XAR1 Protein

Bezeichner auf Proteinebene für ACVR2B

activin A receptor, type IIB , activin receptor type IIB , activin receptor type-2B-like , activin type IIB receptor , activin receptor type-2B , ACTR-IIB , testicular activin receptor IIB , ActRIIB type II activin receptor B , Activine receptor 2b (transmembrane serine kinase) , activin receptor IIB

443156 Ovis aries
460271 Pan troglodytes
100456564 Pongo abelii
448641 Xenopus (Silurana) tropicalis
696071 Macaca mulatta
100053588 Equus caballus
93 Homo sapiens
399277 Xenopus laevis
374213 Gallus gallus
485590 Canis lupus familiaris
448845 Sus scrofa
282131 Bos taurus
25366 Rattus norvegicus
30457 Danio rerio
11481 Mus musculus
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