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anti-Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) Antikörper

Bezeichnung:
anti-Adrenergic, Beta, Receptor Kinase 1 Antikörper (ADRBK1)
Auf www.antikoerper-online.de finden Sie aktuell 130 Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) Antikörper von 21 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Adrenergic, Beta, Receptor Kinase 1 Kits (15) und Adrenergic, Beta, Receptor Kinase 1 Proteine (9) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 169 Adrenergic, Beta, Receptor Kinase 1 Produkte verfügbar.
Synonyme:
Adrbk-1, Bark-1, BARK1, BETA-ARK1, betaARK1, GRK-2, Grk2
Alle Antikörper anzeigen Gen GeneID UniProt
ADRBK1 110355  
ADRBK1 156 P25098
ADRBK1 25238 P26817

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Am meisten referenzierte anti-Adrenergic, Beta, Receptor Kinase 1 Antikörper

  1. Human Polyclonal ADRBK1 Primary Antibody für IHC (p), WB - ABIN1882061 : Eichmann, Lorenz, Hoffmann, Brockmann, Krasel, Lohse, Quitterer: The amino-terminal domain of G-protein-coupled receptor kinase 2 is a regulatory Gbeta gamma binding site. in The Journal of biological chemistry 2003 (PubMed)
    Zeige alle 6 Referenzen für ABIN1882061

  2. Human Monoclonal ADRBK1 Primary Antibody für ICC, IHC - ABIN969178 : Chen, Long, Wu, Jiang, Ma: EGF transregulates opioid receptors through EGFR-mediated GRK2 phosphorylation and activation. in Molecular biology of the cell 2008 (PubMed)
    Zeige alle 2 Referenzen für ABIN969178

  3. Dog (Canine) Polyclonal ADRBK1 Primary Antibody für WB - ABIN374657 : Iaccarino, Barbato, Cipolletta, De Amicis, Margulies, Leosco, Trimarco, Koch: Elevated myocardial and lymphocyte GRK2 expression and activity in human heart failure. in European heart journal 2005 (PubMed)

Weitere Antikörper gegen Adrenergic, Beta, Receptor Kinase 1 Interaktionspartner

Mouse (Murine) Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) Interaktionspartner

  1. GRK2 down-regulation is cardioprotective during diet-induced obesity, reinforcing the protective effect of maintaining low levels of GRK2 under nutritional stress, and showing a role for this kinase in obesity-induced cardiac remodeling and steatosis.

  2. The betaARKrgs peptide, but not endogenous GRK2, interacted with Galpha(q (zeige GNAQ Antikörper)) and interfered with signaling through this G protein. These data support the development of GRK2-based therapeutic approaches to prevent hypertrophy and heart failure.

  3. GRK2 is localized in the mitochondria and its kinase activity negatively impacts the function of this organelle by increasing superoxide levels and altering substrate utilization for energy production.

  4. Erythropoietin (zeige EPO Antikörper) seems to reverse sepsis-induced vasoplegia to NE through the preservation of alpha1D adrenoceptor mRNA/protein expression, inhibition of GRK2-mediated desensitization, and attenuation of NO overproduction in the mouse aorta.

  5. In vitro, GRK2 inhibits Epac1 (zeige RAPGEF3 Antikörper)-to-Rap1 (zeige TERF2IP Antikörper) signaling by phosphorylation of Epac1 (zeige RAPGEF3 Antikörper) at Ser (zeige SIGLEC1 Antikörper)-108 in the Disheveled/Egl-10/pleckstrin (zeige PLEK Antikörper) domain. GRK2 inhibits Epac1 (zeige RAPGEF3 Antikörper)-mediated sensitization of Piezo2 (zeige FAM38B Antikörper) which contributes to inflammatory mechanical hyperalgesia.

  6. GRK2 ablation increases circadian amplitude and decreases circadian period. GRK2 suppresses mPeriod1 transcription,PERIOD1/2 nuclear trafficking and promotes PERIOD2 phosphorylation.

  7. These results suggest GRK2 contributes to melanopsin (zeige OPN4 Antikörper) deactivation, but that other mechanisms account for most of modulation of melanopsin (zeige OPN4 Antikörper) activity in ipRGCs.

  8. data suggest that inhibiting GRK2 could reverse an established insulin (zeige INS Antikörper)-resistant and obese phenotype

  9. Post-MI AdipoR1 (zeige ADIPOR1 Antikörper) phosphorylation positively correlated with the expression level of GRK2. AdipoR1 (zeige ADIPOR1 Antikörper) is phosphorylatively modified and desensitized by GRK2 in failing cardiomyocytes, contributing to post-MI remodeling and HF progression.

  10. findings indicate that the balance between mechanisms regulating vascular tone are shifted to favor vasoconstriction in the absence of GRK2 expression and that this leads to the age-dependent development of hypertension

Cow (Bovine) Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) Interaktionspartner

  1. Mitochondrial-targeted GRK2 is essential for prodeath signaling occurring after oxidative stress in myocytes and assigning a novel role for this GRK (zeige GRK4 Antikörper).

  2. Indicate that the anti-proliferative function of elevated GRK2 in hepatocellular carcinoma is associated with delayed cell cycle progression and is GRK2 kinase activity-dependent.

  3. G alpha q/11 interacts with this protein. A novel surface on a regulator of G protein signals a homology domain for binding G alpha subunits (GRK2 kinase}

  4. determined the crystallographic structure of GRK2 in complex with G protein beta1gamma2 subunits.

  5. intramolecular interactions could play a role in regulating G protein-coupled receptor kinase 2 (GRK2).

  6. epithelial Na-channels are maintained in the active state by Grk2; Grk2 phosphorylates the C terminus of the channel beta subunit (zeige POLG Antikörper) and renders the channels insensitive to inhibition by Nedd4-2 (zeige NEDD4L Antikörper).

  7. Crystallographic and biochemical studies provide evidence that the major domain interfaces of G protein-coupled beta adrenergic receptor kinase 1 (GRK2) remain associated during Gbetagamma binding and activation of GRK2.

  8. Resultrs suggest that activated platelet-derived growth factor receptor-beta (zeige PDGFRB Antikörper) (PDGFRbeta) phosphorylates GRK2 tyrosyl residues and thereby activates GRK2, which then serine-phosphorylates and desensitizes the PDGFRbeta.

  9. GRK2-as5 has a role in membrane trafficking of the mu-opioid receptor (zeige OPRM1 Antikörper)

  10. atomic structure of GRK2 in complex with Galphaq (zeige GNAQ Antikörper) and Gbetagamma, in which activated Galpha (zeige SUCLG1 Antikörper) subunit of Gq is fully dissociated from Gbetagamma and dramatically reoriented from its position in the inactive Galphabetagamma heterotrimer [Galphaq (zeige GNAQ Antikörper), Gbetagamma

Human Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) Interaktionspartner

  1. Our data suggest that GRK2 acts as an important onco-modulator by strengthening the functionality of key players in breast tumorigenesis such as HDAC6 (zeige HDAC6 Antikörper) and Pin1 (zeige PIN1 Antikörper).

  2. GRK2 may inhibit IGF1 (zeige IGF1 Antikörper)-induced human hepatocellular carcinoma cell growth and migration through downregulation of EGR1 (zeige EGR1 Antikörper).

  3. It is a critical factor in diabetic endothelial dysfunction and plays a role in many physiological functions including regulation of G-protein-coupled receptors (GPCRs). (review)

  4. Suggest a common regulatory pattern for the beta(2)-AR/GRK2 which is independent of cellular type or pathology.

  5. Suggest role for GRK2 in the regulating cardiac hypertrophy.

  6. the dual-specific GRK2 and ERK (zeige EPHB2 Antikörper) cascade inhibitor, RKIP (Raf kinase inhibitor protein (zeige PEBP1 Antikörper)), triggered dysfunctional cardiomyocyte energetics and the expression of heart failure-promoting Pparg (zeige PPARG Antikörper)-regulated genes.

  7. Acute mental stress significantly increased GRK2 density in in peripheral blood mononuclear cells of young adult males.

  8. It plays a role in progression of Vasculature which is affected by insulin (zeige INS Antikörper) resistance and type 2 diabetes expresses high levels of GRK2

  9. Data suggest that, by targeting/repressing GRK2, microRNA-K3 of Kaposi sarcoma-associated herpesvirus (KSHV) facilitates migration and invasion of vascular endothelial cells via activation of CXCR2 (zeige CXCR2 Antikörper)/AKT (zeige AKT1 Antikörper) signaling.

  10. Acute aerobic exercise induces a greater GRK2 expression in women than men, while increased cardiorespiratory fitness is associated with exercise-induced GRK2 expression in PBMCs

Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) Antigen-Profil

Beschreibung des Gens

The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.

Alternative names and synonyms associated with Adrenergic, Beta, Receptor Kinase 1 (ADRBK1)

  • beta-adrenergic receptor kinase 1 (Tsp_00497) Antikörper
  • adrenergic, beta, receptor kinase 1 (adrbk1) Antikörper
  • adrenergic receptor kinase, beta 1 (Adrbk1) Antikörper
  • adrenergic, beta, receptor kinase 1 (ADRBK1) Antikörper
  • adrenergic, beta, receptor kinase 1 (Adrbk1) Antikörper
  • Adrbk-1 Antikörper
  • Bark-1 Antikörper
  • BARK1 Antikörper
  • BETA-ARK1 Antikörper
  • betaARK1 Antikörper
  • GRK-2 Antikörper
  • Grk2 Antikörper

Bezeichner auf Proteinebene für ADRBK1

beta-adrenergic receptor kinase 1 , adrenergic, beta, receptor kinase 1 , G-protein-coupled receptor kinase 2 , beta ARK , beta ARK1 , beta-AR kinase-1 , beta-ARK-1 , beta-adrenergic receptor kinase-1 , G-protein coupled receptor kinase 2 , adrenergic receptor kinase, beta 1 , beta-adrenergic receptor kinase 1 beta ARK1

GENE ID SPEZIES
10901826 Trichinella spiralis
100555775 Anolis carolinensis
110355 Mus musculus
282682 Bos taurus
156 Homo sapiens
25238 Rattus norvegicus
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