anti-FEN1 (FEN1) Antikörper

anti-Flap Structure-Specific Endonuclease 1 Antikörper (FEN1)
Auf finden Sie aktuell 127 Flap Structure-Specific Endonuclease 1 (FEN1) Antikörper von 23 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen FEN1 Proteine (55) und FEN1 Kits (5) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 197 FEN1 Produkte verfügbar.
AW538437, cb879, fen-1, fen1, mf1, rad2, xFEN1a

Meistgesuchte Reaktivitäten zu anti-FEN1 (FEN1) Antikörper

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anti-Mouse (Murine) FEN1 Antikörper:

anti-Human FEN1 Antikörper:

anti-Rat (Rattus) FEN1 Antikörper:

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Am meisten referenzierte anti-FEN1 Antikörper

  1. Human Monoclonal FEN1 Primary Antibody für ICC, IF - ABIN151083 : Qiu, Li, Frank, Shen: Cell cycle-dependent and DNA damage-inducible nuclear localization of FEN-1 nuclease is consistent with its dual functions in DNA replication and repair. in The Journal of biological chemistry 2001 (PubMed)
    Zeige alle 17 Referenzen für 151083

  2. Human Polyclonal FEN1 Primary Antibody für IP, WB - ABIN151786 : Muftuoglu, Wong, Imam, Wilson, Bohr, Opresko: Telomere repeat binding factor 2 interacts with base excision repair proteins and stimulates DNA synthesis by DNA polymerase beta. in Cancer research 2006 (PubMed)
    Zeige alle 7 Referenzen für 151786

  3. Human Polyclonal FEN1 Primary Antibody für ICC, IF - ABIN151787 : Farina, Shin, Kim, Bermudez, Kelman, Seo, Hurwitz: Studies with the human cohesin establishment factor, ChlR1. Association of ChlR1 with Ctf18-RFC and Fen1. in The Journal of biological chemistry 2008 (PubMed)
    Zeige alle 6 Referenzen für 151787

  4. Dog (Canine) Monoclonal FEN1 Primary Antibody für BI, WB - ABIN968459 : Harrington, Lieber: The characterization of a mammalian DNA structure-specific endonuclease. in The EMBO journal 1994 (PubMed)
    Zeige alle 5 Referenzen für 968459

  5. Human Polyclonal FEN1 Primary Antibody für IF, WB - ABIN389376 : Hiraoka, Harrington, Gerhard, Lieber, Hsieh: Sequence of human FEN-1, a structure-specific endonuclease, and chromosomal localization of the gene (FEN1) in mouse and human. in Genomics 1995 (PubMed)
    Zeige alle 3 Referenzen für 389376

  6. Human Polyclonal FEN1 Primary Antibody für IF, IHC - ABIN1533720 : Taylor, Noguchi, Totoki, Toyoda, Kuroki, Dewar, Lloyd, Itoh, Takeda, Kim, She, Barlow, Bloom, Bruford, Chang, Cuomo, Eichler, FitzGerald, Jaffe, LaButti, Nicol, Park, Seaman, Sougnez, Yang, Zimmer et al.: Human chromosome 11 DNA sequence and analysis including novel gene identification. ... in Nature 2006 (PubMed)
    Zeige alle 2 Referenzen für 1533720

  7. Cow (Bovine) Polyclonal FEN1 Primary Antibody für WB - ABIN2782483 : Liu, Qiu, Finger, Zheng, Shen: The DNA-protein interaction modes of FEN-1 with gap substrates and their implication in preventing duplication mutations. in Nucleic acids research 2006 (PubMed)

Weitere Antikörper gegen FEN1 Interaktionspartner

Arabidopsis thaliana Flap Structure-Specific Endonuclease 1 (FEN1) Interaktionspartner

  1. Data show that shade avoidance 6 (SAV6; At5g26680), encodes flap endonuclease-1 (FEN1), assures proper root development through maintenance of genome integrity.

Mouse (Murine) Flap Structure-Specific Endonuclease 1 (FEN1) Interaktionspartner

  1. These results reveal an important role of FEN1 phosphorylation to counteract oxygen-induced stress in the heart during the fetal-to-neonatal transition.

  2. WDR4 (zeige WDR4 Antikörper) regulates FEN1's potential DNA cleavage threat near the site of replication.

  3. The FEN1 E359K germline mutation disrupts the FEN1-WRN interaction and FEN1 GEN (zeige GEN1 Antikörper) activity, causing aneuploidy-associated cancers.

  4. PARP1 (zeige PARP1 Antikörper) is required for FEN1 recruitment to DNA repair intermediates in base excision repair.

  5. FFAA Fen1 mutation causes defective Pcna (zeige PCNA Antikörper) -coordinated Okazaki fragment maturation.

  6. A point mutation in the base excision repair gene flap endonuclease 1 causes a functional deficiency in repairing base damage, such that individuals carrying the mutation or similar mutations are predisposed to chemical-induced cancer development.

  7. FEN1 localization within the mitochondrial compartment of mouse brain tissue

  8. Distinct roles for two Mg2 (zeige MCOLN1 Antikörper)+ binding sites in the regulation of FEN-1 nuclease (zeige DCLRE1C Antikörper) activities include enhancement of DNA substrate binding ability and modulation of conformational changes.

  9. FEN1 has roles in DNA repair, as well as in DNA replication

  10. Fen1 is induced independently in mouse embryonic fibroblasts by ultraviolet (UV-C)light

Human Flap Structure-Specific Endonuclease 1 (FEN1) Interaktionspartner

  1. Data indicate that human cancer-associated genetic alterations in the FEN1 gene can contribute substantially to cancer development.

  2. WRN (zeige RECQL2 Antikörper) or the Bloom syndrome helicase (BLM) stimulates DNA polymerase delta (zeige POLD1 Antikörper) progression across telomeric G-rich repeats, only WRN (zeige RECQL2 Antikörper) promotes sequential strand displacement synthesis and FEN1 cleavage.

  3. The FEN1 rs174538 A allele is a protective biomarker for childhood ALL and this association is more significant in males and in patients at onset age of 3.5 years or older.

  4. Data indicate that Flap endonuclease 1 (FEN1) single nucleotide polymorphisms and haplotypes are associated with gallbladder cancer risk.

  5. the aim of the present study was to determine the role of FEN1 in the chemosensitivity of SGC7901 cells.

  6. Binding of DNA to human FEN1 in a bent conformation occurred independently of 5'-flap (zeige ALOX5AP Antikörper) accommodation and did not require active site metal ions or the presence of conserved active site residues.

  7. In this study, we found that cohesion establishment factors, like CHlR1 (zeige DDX11 Antikörper), cooperatively stimulate endonuclease activity of hFen1 in in vivo mimic condition, including replication protein-A (zeige GPR153 Antikörper)-coated DNA and high salt.

  8. Under DNA repair conditions, FEN1 efficiently repaired the 5'-phoshotyrosyl bond-containing SSB substrates in the presence of DNA ligase and DNA polymerase (zeige POLB Antikörper).

  9. WDR4 (zeige WDR4 Antikörper) regulates FEN1's potential DNA cleavage threat near the site of replication.

  10. Patients with expression of both FEN1 and RAD54B (zeige RAD54B Antikörper) were prone to have advanced nodal involvement and significantly poor prognosis.

FEN1 Antigen-Profil

Beschreibung des Gens

The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions.

Alternative names and synonyms associated with FEN1

  • flap structure-specific endonuclease 1 (FEN1) Antikörper
  • flap endonuclease 1-like (LOC100808044) Antikörper
  • Flap endonuclease-1 (Bm1_49605) Antikörper
  • flap endonuclease-1 (AT5G26680) Antikörper
  • flap structure specific endonuclease 1 (Fen1) Antikörper
  • flap structure-specific endonuclease 1 (fen1) Antikörper
  • flap structure-specific endonuclease 1 (fen1-a) Antikörper
  • flap structure-specific endonuclease 1 (Fen1) Antikörper
  • nuclease, Rad2 family (FEN1) Antikörper
  • AW538437 Antikörper
  • cb879 Antikörper
  • fen-1 Antikörper
  • fen1 Antikörper
  • mf1 Antikörper
  • rad2 Antikörper
  • xFEN1a Antikörper

Bezeichner auf Proteinebene für FEN1

flap endonuclease 1 , Flap structure-specific endonuclease 1 , flap structure-specific endonuclease 1 , DNase IV , maturation factor 1 , maturation factor-1 , 5' nuclease xFEN1a , FEN-1-A , flap endonuclease 1-A , flap structure-specific endonuclease 1-A , xFEN-1a , FEN-1

100059838 Equus caballus
100808044 Glycine max
6104806 Brugia malayi
832721 Arabidopsis thaliana
14156 Mus musculus
2237 Homo sapiens
386707 Danio rerio
394303 Xenopus laevis
769677 Gallus gallus
476063 Canis lupus familiaris
616242 Bos taurus
84490 Rattus norvegicus
100307042 Ovis aries
5721250 Chlamydomonas reinhardtii
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