anti-Caspase 1 (CASP1) Antikörper

anti-Caspase 1 Antikörper (CASP1)
Auf finden Sie aktuell 280 Caspase 1 (CASP1) Antikörper von 32 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Caspase 1 Kits (57) und Caspase 1 Proteine (35) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 393 Caspase 1 Produkte verfügbar.
CASP1, ccp1, CG5370, dcp-1, dcp1, Dmel\\CG5370, Ice, Il1bc, l(2)01862, l(2)02132, P45
Alle Antikörper anzeigen Gen GeneID UniProt
CASP1 834 P29466
CASP1 12362 P29452
CASP1 25166  

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Weitere Synonyme anzeigen

Meistgesuchte Reaktivitäten zu anti-Caspase 1 (CASP1) Antikörper

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anti-Human Caspase 1 Antikörper:

anti-Mouse (Murine) Caspase 1 Antikörper:

anti-Rat (Rattus) Caspase 1 Antikörper:

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Am meisten referenzierte anti-Caspase 1 Antikörper

  1. Human Monoclonal Caspase 1 Primary Antibody für IHC, IHC (p) - ABIN252521 : Dorfleutner, Bryan, Talbott, Funya, Rellick, Reed, Shi, Rojanasakul, Flynn, Stehlik: Cellular pyrin domain-only protein 2 is a candidate regulator of inflammasome activation. in Infection and immunity 2007 (PubMed)
    Zeige alle 24 Referenzen für 252521

  2. Human Monoclonal Caspase 1 Primary Antibody für IHC (p), ELISA - ABIN393212 : Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. in Diabetes Care 2010 (PubMed)
    Zeige alle 5 Referenzen für 393212

  3. Human Polyclonal Caspase 1 Primary Antibody für IF, IP - ABIN222877 : Peluffo, Bussmann, Stouffer, Tesone: Expression of caspase-2, -3, -8 and -9 proteins and enzyme activity in the corpus luteum of the rat at different stages during the natural estrous cycle. in Reproduction (Cambridge, England) 2006 (PubMed)
    Zeige alle 5 Referenzen für 222877

  4. Human Polyclonal Caspase 1 Primary Antibody für IHC, ELISA - ABIN1532666 : Thornberry, Bull, Calaycay, Chapman, Howard, Kostura, Miller, Molineaux, Weidner, Aunins: A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes. in Nature 1992 (PubMed)
    Zeige alle 3 Referenzen für 1532666

  5. Dog (Canine) Monoclonal Caspase 1 Primary Antibody für IF, WB - ABIN968350 : Akiyama, Yokota, Kagawa, Shimbara, DeMartino, Slaughter, Noda, Tanaka: cDNA cloning of a new putative ATPase subunit p45 of the human 26S proteasome, a homolog of yeast transcriptional factor Sug1p. in FEBS letters 1995 (PubMed)
    Zeige alle 3 Referenzen für 968350

  6. Human Polyclonal Caspase 1 Primary Antibody für IHC, ELISA - ABIN1531644 : Feng, Li, Leung, Auersperg: Caspase-1zeta, a new splice variant of the caspase-1 gene. in Genomics 2004 (PubMed)
    Zeige alle 3 Referenzen für 1531644

  7. Human Polyclonal Caspase 1 Primary Antibody für ELISA, WB - ABIN1536100 : Cerretti, Kozlosky, Mosley, Nelson, Van Ness, Greenstreet, March, Kronheim, Druck, Cannizzaro: Molecular cloning of the interleukin-1 beta converting enzyme. in Science (New York, N.Y.) 1992 (PubMed)
    Zeige alle 3 Referenzen für 1536100

  8. Human Polyclonal Caspase 1 Primary Antibody für IHC (p), WB - ABIN115381 : Walker, Talanian, Brady, Dang, Bump, Ferenz, Franklin, Ghayur, Hackett, Hammill: Crystal structure of the cysteine protease interleukin-1 beta-converting enzyme: a (p20/p10)2 homodimer. in Cell 1994 (PubMed)
    Zeige alle 2 Referenzen für 115381

  9. Human Polyclonal Caspase 1 Primary Antibody für IHC, IHC (p) - ABIN4287999 : Dumas, Amiable, de Rivero Vaccari, Chae, Keane, Lacroix, Vallières: The inflammasome pyrin contributes to pertussis toxin-induced IL-1β synthesis, neutrophil intravascular crawling and autoimmune encephalomyelitis. in PLoS pathogens 2014 (PubMed)

  10. Human Polyclonal Caspase 1 Primary Antibody für ICC, IF - ABIN4288006 : Kariya, Okano, Zhao, Kataoka, Yoshinobu, Maeda, Ishihara, Higaki, Nishizaki: Activation of NLRP3 inflammasome in human middle ear cholesteatoma and chronic otitis media. in Acta oto-laryngologica 2016 (PubMed)

Weitere Antikörper gegen Caspase 1 Interaktionspartner

Fruit Fly (Drosophila melanogaster) Caspase 1 (CASP1) Interaktionspartner

  1. drICE (zeige CASP3 Antikörper) and dcp-1 (zeige ACE Antikörper) function in cell death redundantly. However, dying neurons in a few clusters strictly required drICE (zeige CASP3 Antikörper) but not dcp-1 (zeige ACE Antikörper), but required drICE (zeige CASP3 Antikörper) and dcp-1 (zeige ACE Antikörper) when drICE (zeige CASP3 Antikörper) activity was reduced via hypomorphic mutation.

  2. Drosophila corazonin-producing interneuron programmed cell death utilizes dronc, strica, dcp-1 (zeige ACE Antikörper), and ice

  3. Autophagy suppresses Dcp-1 (zeige ACE Antikörper)-mediated apoptotic cell death, whereas Dcp-1 (zeige ACE Antikörper) positively regulates autophagy, possibly through feedback regulation.

  4. novel characteristic morphological features of egg chambers lacking both dcp-1 (zeige ACE Antikörper) and pita functions in the germline cells; suggested an essential role of dcp-1 (zeige ACE Antikörper) and/or pita during mid-oogenesis

  5. A double-mutant analysis between drICE (zeige CASP3 Antikörper) and death caspase-1 (dcp-1), another effector caspase (zeige CASP3 Antikörper), reveals that some cells (type I) strictly require drICE (zeige CASP3 Antikörper) for apoptosis, whereas other cells (type II) require either drICE (zeige CASP3 Antikörper) or dcp-1 (zeige ACE Antikörper).

  6. Data show that the effector caspase Dcp-1 and the inhibitor of apoptosis protein (zeige BIRC2 Antikörper) Bruce (zeige BIRC6 Antikörper) function to regulate both autophagy and starvation-induced cell death in Drosophila.

  7. HeT-A mRNA is derepressed in mRNA degradation mutants dcp1 (zeige ACE Antikörper), indicating that the enzyme also aid in removing full-length transcripts and/or decay intermediates.

Silk Worm Caspase 1 (CASP1) Interaktionspartner

  1. cBm-IAP1 (zeige BIRC3 Antikörper) is a vital negative regulator of apoptosis in BM-N cells and functions by preventing the activation and/or activity of Bm-Dronc and Bm-caspase-1.

  2. Activation of Atg5 (zeige ATG5 Antikörper), AIF (zeige AIFM1 Antikörper) and caspase (zeige CASP3 Antikörper) genes in close association with different cell death events revealed the synchronized differential expression of apoptosis-associated genes in response to macroparasitism.

Mouse (Murine) Caspase 1 (CASP1) Interaktionspartner

  1. The most well-known function of active caspase-1 is to cleave the proforms of inflammatory cytokines IL-1beta (zeige IL1B Antikörper) and -18 into their active forms in response to inflammatory stimuli in immune cells. Caspase-1 has multiple functions in addition to this cytokine maturation role. It is at the center of many cell responses to stress and inflammation not just in immune cells but in other cell types, such as epithelia. Review.

  2. Findings demonstrate a critical role of caspase-1 in macrophage-driven inflammation in the adipose tissue and the development of obesity.

  3. Inflammasome NLRP3 (zeige NLRP3 Antikörper)-caspase-1-mediated degradation of smooth muscle cell contractile proteins may contribute to aortic biomechanical dysfunction and aortic aneurysm/dissection development.

  4. Data indicate that NLRC4 (zeige NLRC4 Antikörper) activation in Intestinal epithelial cells (IECs) leads to cell expulsion and IL-18 (zeige IL18 Antikörper) release, and implicate Caspase-8 (zeige CASP8 Antikörper) in NLRC4 (zeige NLRC4 Antikörper) inflammasome responses in vivo by generation of doubly deficient in Caspase-1 and Caspase-8 (zeige CASP8 Antikörper).

  5. our studies have uncovered a specific role for caspase-1-mediated IL-1beta (zeige IL1B Antikörper) release in the manifestation of Familial Mediterranean Fever (zeige MEFV Antikörper)

  6. variant p.C284A caspase-1 stabilizes pyroptosome formation, potentially enhancing inflammation by two IL-1beta (zeige IL1B Antikörper)-independent mechanisms: pyroptosomes convey an enhanced inflammatory stimulus through the recruitment of additional proteins (such as RIP2 (zeige ARHGDIG Antikörper), receptor interacting protein (zeige RIPK1 Antikörper) kinase 2 (zeige PKC Antikörper)), which is further amplified through pyroptosome and cell division.

  7. TNF-alpha (zeige TNF Antikörper) induces caspase-1 activation in an inflammasome-independent manner in 3T3-L1 cells and that the ERK (zeige EPHB2 Antikörper)-dependent expression of NLRP3 (zeige NLRP3 Antikörper) may play a role independently of its canonical role as a component of inflammasomes.

  8. caspase-1 activation is an upstream event of apoptotic caspase-7 (zeige CASP7 Antikörper) induction in renal tubulointerstitial fibrosis

  9. it was found that GSK2656157 specifically inhibited ER stress induced by large amount of LPS (zeige TLR4 Antikörper) and reduced LPS (zeige TLR4 Antikörper)-induced IL-1beta (zeige IL1B Antikörper) production through inhibition of Caspase 1 activation.

  10. Study suggests that Casp1 has a limited role in the development of burn-induced pain.

Human Caspase 1 (CASP1) Interaktionspartner

  1. Proteases caspase-1 and caspase-8 (zeige CASP8 Antikörper) have redundant roles in cleaving IL-1beta (zeige IL1B Antikörper) and promoting osteomyelitis. [review]

  2. Patients with NLRP1 (zeige NLRP1 Antikörper)-associated autoinflammation with arthritis and dyskeratosis syndrome had increased systemic CASP1.

  3. The biochemical function of NLPR3 inflammasomes is to activate caspase-1, which leads to the maturation of interleukin 1 beta (zeige IL1B Antikörper) and IL-18 (zeige IL18 Antikörper) and the induction of pyroptosis, a form of cell death. (Review)

  4. The structure of the human caspase-1 CARD domain (caspase-1(CARD)) filament solved by cryo-electron microscopy.

  5. Caspase-1-mediated downregulation of PPARgamma (zeige PPARG Antikörper) was important in the late stage of monocyte-macrophage differentiation; however, PPARgamma (zeige PPARG Antikörper) protein levels had little effect on the early stage differentiation.

  6. Inflammasome NLRP3 (zeige NLRP3 Antikörper)-caspase-1-mediated degradation of smooth muscle cell contractile proteins may contribute to aortic biomechanical dysfunction and aortic aneurysm/dissection development.

  7. Study demonstrates that the expression of the NLRP3 (zeige NLRP3 Antikörper)-caspase-1-IL-18 (zeige IL18 Antikörper) axis is highly expressed in the peripheral blood mononuclear cells of patients with bullous pemphigoid (zeige DST Antikörper) (BP), and correlated with disease activity, suggesting its involvement in the pathogenesis and progression of BP.

  8. High expression of CASP1 is associated with osteosarcoma.

  9. This study demonstrated that dysregulated expression of NLRP3 (zeige NLRP3 Antikörper)-caspase-1-IL-1beta (zeige IL1B Antikörper) axis was observed in patients with MM, suggesting they might be involved in the pathogenesis of MM.

  10. The NLRP3 (zeige NLRP3 Antikörper)/caspase-1/IL-1beta (zeige IL1B Antikörper) axis is active in cartilaginous endplates of patients with Modic changes and inflammatory cascades can exacerbate the cartilaginous endplate degeneration which may act as a trigger for intervertebral disc degeneration and low back pain.

Pig (Porcine) Caspase 1 (CASP1) Interaktionspartner

  1. Src kinase (zeige CSK Antikörper) mediates hypoxia-induced caspase-1 activation in the cerebral cortex of newborn piglets

  2. endometrial expression of CASP1 and IL18 (zeige IL18 Antikörper) associated with pregnancy establishment; alteration of CASP1 and IL18 (zeige IL18 Antikörper) following premature exposure of uterus to estrogen during early pregnancy may contribute to conceptus loss between Days 15 to 18 of pregnancy

Caspase 1 (CASP1) Antigen-Profil

Beschreibung des Gens

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.

Alternative names and synonyms associated with Caspase 1 (CASP1)

  • caspase 1, apoptosis-related cysteine peptidase (CASP1) Antikörper
  • caspase 1 (Casp1) Antikörper
  • caspase 4, apoptosis-related cysteine peptidase (CASP4) Antikörper
  • Death caspase-1 (Dcp-1) Antikörper
  • caspase-1 (Ice) Antikörper
  • caspase-1 (AaeL_AAEL014348) Antikörper
  • caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) (CASP1) Antikörper
  • caspase-1-like (LOC100725217) Antikörper
  • caspase 1 (LOC100101588) Antikörper
  • CASP1 Antikörper
  • ccp1 Antikörper
  • CG5370 Antikörper
  • dcp-1 Antikörper
  • dcp1 Antikörper
  • Dmel\\CG5370 Antikörper
  • Ice Antikörper
  • Il1bc Antikörper
  • l(2)01862 Antikörper
  • l(2)02132 Antikörper
  • P45 Antikörper

Bezeichner auf Proteinebene für anti-Caspase 1 (CASP1) Antikörper

CASP1 nirs variant 1 , IL-1 beta-converting enzyme , IL1B-convertase , caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) , caspase-1 , interleukin 1, beta, convertase , interleukin 1-B converting enzyme , CASP-1 , IL-1B converting enzyme , IL-1BC , interleukin 1 beta-converting enzyme , interleukin-1 beta convertase , interleukin-1 beta-converting enzyme , p45 , Interleukin 1beta converting enzyme , caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, convertase) , ICE , interleukin-1 beta converting enzyme , caspase-1/caspase-4 hybrid , CG5370-PA , Dcp-1-PA , caspase , caspase 1 , death caspase-1

834 Homo sapiens
12362 Mus musculus
25166 Rattus norvegicus
395764 Gallus gallus
397319 Sus scrofa
403724 Canis lupus familiaris
37729 Drosophila melanogaster
692604 Bombyx mori
5564196 Aedes aegypti
100033888 Equus caballus
451519 Pan troglodytes
514214 Bos taurus
100437679 Pongo abelii
100588974 Nomascus leucogenys
706568 Macaca mulatta
100725217 Cavia porcellus
100101588 Oryctolagus cuniculus
493961 Felis catus
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