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ERBB3 Antikörper (C-Term)

Dieser Maus Monoklonal Antikörper detektiert spezifisch ERBB3 in WB. Es zeigt Reaktivität gegenüber Proben von Human.
Produktnummer ABIN126793
840,00 €
Zzgl. Versandkosten 20,00 € und MwSt
0.1 mg
Lieferung nach: Deutschland
Lieferung in 16 Werktagen

Kurzübersicht für ERBB3 Antikörper (C-Term) (ABIN126793)

Target

Alle ERBB3 Antikörper anzeigen
ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))

Reaktivität

  • 225
  • 126
  • 102
  • 17
  • 7
  • 5
  • 3
  • 3
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
Human

Wirt

  • 206
  • 38
  • 17
  • 1
Maus

Klonalität

  • 165
  • 97
Monoklonal

Konjugat

  • 128
  • 21
  • 7
  • 6
  • 6
  • 6
  • 6
  • 6
  • 6
  • 6
  • 6
  • 5
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 3
  • 3
  • 2
  • 1
Dieser ERBB3 Antikörper ist unkonjugiert

Applikation

  • 136
  • 74
  • 69
  • 53
  • 53
  • 51
  • 29
  • 29
  • 28
  • 26
  • 16
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
Western Blotting (WB)

Klon

11A4
  • Bindungsspezifität

    • 27
    • 26
    • 25
    • 15
    • 15
    • 15
    • 9
    • 8
    • 7
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term

    Spezifität

    This antibody specifically recognizes the C-terminus of erbB3 at 185 kDa.

    Produktmerkmale

    Synonyms: ERBB-3, c-erbB-3, HER-3, Receptor tyrosine-protein kinase erbB-3, Tyrosine kinase-type cellsurface receptor HER3, Proto-oncogene-like protein c-ErbB-3

    Aufreinigung

    Subsequent Thiophilic Adsorption and Size Exclusion Chromatography

    Bestandteile

    incl. positive Control

    Immunogen

    Synthetic petide conjugated to KLH.

    Isotyp

    IgG1
  • Applikationshinweise

    Western Blot: 0.5 μg/mL for HRPO/ECL detection. Recommended blocking buffer: Casein/Tween 20 based blocking and blot incubationbuffer.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Rekonstitution

    Restore with 1 mL H2O (15 min, RT)

    Buffer

    1 mLPBS, 0.09 % Sodium Azide, PEG and Sucrose

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C/-80 °C

    Informationen zur Lagerung

    Store lyophilized (preferably in a desiccator) at -20 °C and reconstituted (aliquote andfreeze in liquid nitrogen) at -80 °C. Avoid repeated freezing and thawing. Thaw aliquots at 37 °C. Thawed aliquots may be stored at 4 °C up to 3 months.
    Shelf life: one year from despatch.

    Haltbarkeit

    12 months
  • Target

    ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))

    Andere Bezeichnung

    ERBB3 / HER3

    Hintergrund

    ErbB3 is a member of the EGFR/erbB receptor tyrosine kinase family. ErbB3 lacks intrinsic kinase activity due to an amino acid substitution within the ATP binding site. Upon heterodimerization with the other erbB family members, erbB3 becomes phosphorylated at multiple tyrosine residues that represent docking sites for downstream signaling proteins, e.g. PI3K, grb7 and shc. The erbB3 cytoplasmic domain contains 6 docking sites for PI3K. Thus, erbB3 is a potent activator of the PI3K/PKB signaling pathway.Synonyms: ERBB-3, HER-3, Proto-oncogene-like protein c-ErbB-3, Receptor tyrosine-protein kinase erbB-3, Tyrosine kinase-type cell surface receptor HER3, c-erbB-3

    Molekulargewicht

    185 kDa

    Gen-ID

    2065

    UniProt

    P21860

    Pathways

    RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung
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