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SEC31A Antikörper (AA 522-719)

SEC31A Reaktivität: Human WB, IF Wirt: Maus Monoclonal 32-Sec31A unconjugated
Produktnummer ABIN968830
  • Target Alle SEC31A Antikörper anzeigen
    SEC31A (SEC31 Homolog A (SEC31A))
    Bindungsspezifität
    • 8
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 522-719
    Reaktivität
    • 31
    • 13
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 23
    • 9
    Maus
    Klonalität
    • 23
    • 9
    Monoklonal
    Konjugat
    • 16
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SEC31A Antikörper ist unkonjugiert
    Applikation
    • 19
    • 12
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Human Sec31A aa. 522-719
    Klon
    32-Sec31A
    Isotyp
    IgG1
    Top Product
    Discover our top product SEC31A Primärantikörper
  • Kommentare

    Related Products: ABIN968537, ABIN967389

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store undiluted at -20° C.
  • Tang, Ong, Huang, Wei, Wong, Qi, Horstmann, Hong: "A membrane protein enriched in endoplasmic reticulum exit sites interacts with COPII." in: The Journal of biological chemistry, Vol. 276, Issue 43, pp. 40008-17, (2001) (PubMed).

    Tang, Zhang, Low, Wong, Horstmann, Hong: "Mammalian homologues of yeast sec31p. An ubiquitously expressed form is localized to endoplasmic reticulum (ER) exit sites and is essential for ER-Golgi transport." in: The Journal of biological chemistry, Vol. 275, Issue 18, pp. 13597-604, (2000) (PubMed).

  • Target
    SEC31A (SEC31 Homolog A (SEC31A))
    Andere Bezeichnung
    Sec31A (SEC31A Produkte)
    Synonyme
    ABP125 antikoerper, ABP130 antikoerper, HSPC334 antikoerper, SEC31L1 antikoerper, Sec31l1 antikoerper, VAP1 antikoerper, 1810024J13Rik antikoerper, AU042160 antikoerper, HSPC275 antikoerper, cb354 antikoerper, sec31p antikoerper, zgc:63547 antikoerper, SEC31 homolog A, COPII coat complex component antikoerper, Sec31 homolog A (S. cerevisiae) antikoerper, SEC31A antikoerper, Sec31a antikoerper, sec31a antikoerper
    Hintergrund
    Eukaryotic protein trafficking involves packaging of target molecules into membranous vesicles that bud from a donor compartment, travel to a specific destination, fuse, and release their contents into an acceptor compartment. Vesicles that bud from the Golgi cisternae and from the ER contain a non-clathrin based coat. This coat is an oligomeric complex whose subunits are termed COPs (coatomer proteins). COPI is the golgi- and endosome-associated COP complex, while COPII is the ER-associated coat complex. In yeast, the COPII complex has a cargo binding subcomplex that includes Sar1p, Sec23p, and Sec24p, which recruits Sec13p and Sec31p leading to vesicle formation. The human homologues of Sec31p are Sec31A and Sec31B. Sec31A has 40% identity with Sec31B, and contains an N-terminal WD-40 domain and a C-terminal proline-rich region. Sec31A mRNA is widely expressed, while Sec31B is found only in testis and thymus. In HeLa, Sec31A localizes to vesicular structures in the perinuclear region of the cell, and co-localizes with the COPII component Sec13. Antibodies against Sec31A inhibit ER to Golgi transport of vesicular stomatitis G protein. Thus, Sec31 may be an important COPII component involved in ER to Golgi transport, as well as a marker for COPII vesicles.
    Molekulargewicht
    148 kDa
    Pathways
    ER-Nucleus Signaling
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