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Cullin 3 Antikörper (AA 565-684)

CUL3 Reaktivität: Human, Maus, Ratte, Huhn, Hund WB, IF Wirt: Maus Monoclonal 3-CUL unconjugated
Produktnummer ABIN968679
  • Target Alle Cullin 3 (CUL3) Antikörper anzeigen
    Cullin 3 (CUL3)
    Bindungsspezifität
    • 15
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 565-684
    Reaktivität
    • 53
    • 22
    • 18
    • 6
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    Human, Maus, Ratte, Huhn, Hund
    Wirt
    • 51
    • 1
    • 1
    Maus
    Klonalität
    • 48
    • 5
    Monoklonal
    Konjugat
    • 32
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Cullin 3 Antikörper ist unkonjugiert
    Applikation
    • 25
    • 16
    • 13
    • 13
    • 13
    • 6
    • 6
    • 5
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Kreuzreaktivität
    Maus, Ratte (Rattus), Hund, Huhn
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Human CUL-3 aa. 565-684
    Klon
    3-CUL
    Isotyp
    IgG1
    Top Product
    Discover our top product CUL3 Primärantikörper
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    Related Products: ABIN968545, ABIN967389

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store undiluted at -20° C.
  • Hori, Osaka, Chiba, Miyamoto, Okabayashi, Shimbara, Kato, Tanaka: "Covalent modification of all members of human cullin family proteins by NEDD8." in: Oncogene, Vol. 18, Issue 48, pp. 6829-34, (2000) (PubMed).

    Singer, Gurian-West, Clurman, Roberts: "Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells." in: Genes & development, Vol. 13, Issue 18, pp. 2375-87, (1999) (PubMed).

  • Target
    Cullin 3 (CUL3)
    Andere Bezeichnung
    CUL-3 (CUL3 Produkte)
    Synonyme
    CUL-3 antikoerper, Cullin-3 antikoerper, CUL-3-A antikoerper, Cullin-3-A antikoerper, cul3 antikoerper, cul3a antikoerper, CUL-3-B antikoerper, Cullin-3-B antikoerper, cul3b antikoerper, wu:fc37e01 antikoerper, CUL3 antikoerper, ATCUL3 antikoerper, ATCUL3A antikoerper, CUL3A antikoerper, T24P13.25 antikoerper, cullin 3 antikoerper, cullin 3A antikoerper, PHA2E antikoerper, AI467304 antikoerper, AW146203 antikoerper, mKIAA0617 antikoerper, cullin 3 antikoerper, cullin 3 L homeolog antikoerper, cullin 3 S homeolog antikoerper, cullin-3 antikoerper, Cullin-3 (CUL-3) antikoerper, cullin 3a antikoerper, CULlin antikoerper, CUL3 antikoerper, cul3 antikoerper, cul3.L antikoerper, cul3.S antikoerper, PTRG_11586 antikoerper, Smp_117580 antikoerper, cul3a antikoerper, Cul3 antikoerper, cul-3 antikoerper
    Hintergrund
    The cullins are a family of proteins that are integral to cell cycle regulation. Members of this family include human Cul proteins, C.elegans Ce-Cul-1, and S. cerevisiae Cdc53. Proper control of cell cycle progression is essential for the prevention of tumorigenesis. Mutant forms of both Ce-Cul-1 and Cdc53 have been implicated in the oncogenic process. The human Cul family of proteins, Cul-1, -2, -3, -4A, -4B, and -5, have also been implicated in oncogenic processes. Abnormal nuclear localization of Cul-2 is seen in a rare hereditary condition known as VHL (von Hippel-Lindau) syndrome. Patients with VHL syndrome possess a mutant VHL gene and develop cancers such as retinal anginomas, CNS hemangioblastomas, and renal cell carcinomas. Cul-3 is widely expressed in normal cells and tissues, and shows increased expression in colon cancer cells. Cul-3 can associate with cyclin E in mammalian cells, and overexpression of Cul-3 targets cyclin E for ubiquination, while deletion of Cul-3 in mice leads to increased cyclin E accumulation and abnormal regulation of S-phase. Thus, the Cul family of proteins may have roles in cell cycle regulation and tumoriogenesis. This antibody is routinely tested by western blot analysis.
    Molekulargewicht
    89 kDa
    Pathways
    M Phase
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