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CD38 Antikörper (AA 171-292)

Reaktivität: Human WB, IF Wirt: Maus Monoclonal 22-CD38 unconjugated
Produktnummer ABIN968373
  • Target Alle CD38 Antikörper anzeigen
    CD38
    Bindungsspezifität
    • 19
    • 16
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 171-292
    Reaktivität
    • 157
    • 60
    • 28
    • 12
    • 12
    • 12
    • 1
    • 1
    • 1
    Human
    Wirt
    • 106
    • 81
    • 29
    • 1
    Maus
    Klonalität
    • 147
    • 66
    • 2
    Monoklonal
    Konjugat
    • 67
    • 16
    • 15
    • 13
    • 9
    • 7
    • 7
    • 6
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CD38 Antikörper ist unkonjugiert
    Applikation
    • 166
    • 69
    • 36
    • 35
    • 32
    • 26
    • 26
    • 22
    • 19
    • 18
    • 7
    • 7
    • 6
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Human CD38 aa. 171-292
    Klon
    22-CD38
    Isotyp
    IgG1
    Top Product
    Discover our top product CD38 Primärantikörper
  • Kommentare

    Related Products: ABIN967389, ABIN968584

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store undiluted at -20°C.
  • Deaglio, Morra, Mallone, Ausiello, Prager, Garbarino, Dianzani, Stockinger, Malavasi: "Human CD38 (ADP-ribosyl cyclase) is a counter-receptor of CD31, an Ig superfamily member." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 160, Issue 1, pp. 395-402, (1998) (PubMed).

    Konopleva, Estrov, Zhao, Andreeff, Mehta: "Ligation of cell surface CD38 protein with agonistic monoclonal antibody induces a cell growth signal in myeloid leukemia cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 161, Issue 9, pp. 4702-8, (1998) (PubMed).

  • Target
    CD38
    Abstract
    CD38 Produkte
    Synonyme
    T10 antikoerper, Cd38-rs1 antikoerper, cd38 antikoerper, ADPRC 1 antikoerper, cADPr hydrolase 1 antikoerper, CD38 molecule antikoerper, CD38 antigen antikoerper, CD38 molecule L homeolog antikoerper, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 antikoerper, CD38 antikoerper, Cd38 antikoerper, cd38.L antikoerper
    Hintergrund
    Lymphocyte trafficking is essential for efficient immune responses in that it allows antigen sensitive lymphocytes to encounter antigen and be recruited to sites of infection. Trafficking involves the passage of lymphocytes across the HEV, a process that is mediated by selectins. CD38 is a single-chain type II transmembrane glycoprotein that is expressed by a variety of immature and activated lymphocytes. It mediates a selectin-like binding to endothelial cells, thus functioning as an adhesion molecule. Human and mouse forms of the protein are highly similar and homologous to the Aplysia californica ADP-ribosyl-cyclase. CD38 catalyzes the synthesis of cyclic ADP-ribose (cADPR), a putative endogenous regulator of calcium release. This is thought to be key to CD38-mediated signal transduction. A possible ligand for CD38 is the Ig superfamily protein CD31. In addition, activation of CD38 with a monoclonal antibody induces leukemic cell proliferation. Thus, CD38 is a cell surface protein that is important for lymphocyte migration and may be involved in the propagation of leukemic cells in AML (acute myelogenous leukemia).
    Molekulargewicht
    46 kDa
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