Cytokeratin 7 Antikörper

Produktnummer ABIN967289

Produktdetails anti-Cytokeratin 7 Antikörper

Target: Cytokeratin 7 (KRT7) (Keratin 7 (KRT7))

Reaktivität: Human, Ratte, Maus, Hund, Schwein, Hamster

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Cytokeratin 7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Marke: BD Pharmingen™

Kreuzreaktivität: Maus, Ratte (Rattus), Hamster, Hund, Schwein

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Cytokeratins from the human bladder carcinoma cell line T24

Klon: RCK105

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Applications include western blot analysis. Additional applications include immunohistochemistry on methanol fixed tissue, but this application is not tested.

Kommentare:

Related Products: ABIN968535, ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C.

Referenzen für anti-Cytokeratin 7 Antikörper (ABIN967289)

Smedts, Ramaekers, Robben, Pruszczynski, van Muijen, Lane, Leigh, Vooijs: "Changing patterns of keratin expression during progression of cervical intraepithelial neoplasia." in: The American journal of pathology, Vol. 136, Issue 3, pp. 657-68, (1990) (PubMed).

Broers, Ramaekers, Rot, Oostendorp, Huysmans, van Muijen, Wagenaar, Vooijs: "Cytokeratins in different types of human lung cancer as monitored by chain-specific monoclonal antibodies." in: Cancer research, Vol. 48, Issue 11, pp. 3221-9, (1988) (PubMed).

Ramaekers, Huysmans, Schaart, Moesker, Vooijs: "Tissue distribution of keratin 7 as monitored by a monoclonal antibody." in: Experimental cell research, Vol. 170, Issue 1, pp. 235-49, (1987) (PubMed).

Details zu Cytokeratin 7

Target: Cytokeratin 7 (KRT7) (Keratin 7 (KRT7))

Andere Bezeichnung: Cytokeratin 7 (KRT7 Produkte)

Synonyme: CK7 antikoerper, K2C7 antikoerper, K7 antikoerper, SCL antikoerper, D15Wsu77e antikoerper, Krt2-7 antikoerper, KRT7 antikoerper, keratin 7 antikoerper, KRT7 antikoerper, Krt7 antikoerper

Hintergrund: Intermediate filaments (IF) are a subset of cytoskeletal proteins which function to give overall structural integrity to the plasma membrane as well as organize cells into specific tissues. IF proteins can be divided into six major types based upon similarity in sequence. Type I and II IF proteins are designated keratins based upon whether they are acidic (I) or basic (II) and are characterized by their remarkable biochemical diversity. A subgroup of keratins, designated cytokeratins, are represented in epithelial tissues by at least 20 different polypeptides, designated 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin 7 is found in both columnar and glandular epithelium of the lung, cervix, breast, bile ducts, and in the collecting ducts in the kidney as well as mesothelium. The molecular weight of cytokeratin 7 is approximately 54 kDa in SDS/PAGE.

Molekulargewicht: 55 kDa