TNFRSF11A Antikörper (N-Term)

Produktnummer ABIN966946

Dieser Polyklonal Antikörper detektiert spezifisch TNFRSF11A in WB. Es zeigt Reaktivität gegenüber Proben von Human. Es wurde in 2+ Publikationen zitiert.

Kurzübersicht für TNFRSF11A Antikörper (N-Term) (ABIN966946)

Target: TNFRSF11A (Tumor Necrosis Factor Receptor Superfamily, Member 11a, NFKB Activator (TNFRSF11A))

Reaktivität: Human

Wirt: Bitte anfragen

Klonalität: Polyklonal

Konjugat: Dieser TNFRSF11A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-TNFRSF11A Antikörper

Bindungsspezifität: AA 29-44, N-Term

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminal of human RANK (29-44 aa), identical to the related mouse and rat sequence.

Anwendungsinformationen

Applikationshinweise: WB: The detection limit for RANK is approximately 2.5ng/lane under non-reducing and reducing conditions.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: 0.2ml of distilled water will yield a concentration of 500µg/ml.

Buffer: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4

Konservierungsmittel: Thimerosal (Merthiolate), Sodium azide

Lagerung: -20 °C

Referenzen für anti-TNFRSF11A Antikörper (ABIN966946)

Theill, Boyle, Penninger: "RANK-L and RANK: T cells, bone loss, and mammalian evolution." in: Annual review of immunology, Vol. 20, pp. 795-823, (2002) (PubMed).

Suda, Takahashi, Udagawa, Jimi, Gillespie, Martin: "Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families." in: Endocrine reviews, Vol. 20, Issue 3, pp. 345-57, (1999) (PubMed).

Details zu TNFRSF11A

Target: TNFRSF11A (Tumor Necrosis Factor Receptor Superfamily, Member 11a, NFKB Activator (TNFRSF11A))

Andere Bezeichnung: RANK

Hintergrund: Receptor Activator of Nuclear Factor B (RANK), also known as TRANCE Receptor, is a type I membrane protein that is expressed on the surface of osteoclasts and is involved in their activation upon ligand binding. RANK is also expressed on dendritic cells and facilitates immune signaling.RANKL (Receptor Activator for Nuclear Factor B Ligand) is found on the surface of stromal cells, osteoblasts, and T cells. By analysis of somatic cell and radiation hybrid panels, Anderson et al. (1997) mapped the RANK gene to 18q22.1.

Pathways: NF-kappaB Signalweg