DCLRE1C Antikörper

Produktnummer ABIN965976

Produktdetails anti-DCLRE1C Antikörper

Target: DCLRE1C (DNA Cross-Link Repair 1C (DCLRE1C))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DCLRE1C Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-residues of human DCLRE1C (DNA cross-link repair 1C protein)

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Lagerung: 4 °C

Referenzen für anti-DCLRE1C Antikörper (ABIN965976)

Pannicke, Ma, Hopfner, Niewolik, Lieber, Schwarz: "Functional and biochemical dissection of the structure-specific nuclease ARTEMIS." in: The EMBO journal, Vol. 23, Issue 9, pp. 1987-97, (2004) (PubMed).

Poinsignon, de Chasseval, Soubeyrand, Moshous, Fischer, Haché, de Villartay: "Phosphorylation of Artemis following irradiation-induced DNA damage." in: European journal of immunology, Vol. 34, Issue 11, pp. 3146-55, (2004) (PubMed).

Poinsignon, Moshous, Callebaut, de Chasseval, Villey, de Villartay: "The metallo-beta-lactamase/beta-CASP domain of Artemis constitutes the catalytic core for V(D)J recombination." in: The Journal of experimental medicine, Vol. 199, Issue 3, pp. 315-21, (2004) (PubMed).

Ma, Lu, Tippin, Goodman, Shimazaki, Koiwai, Hsieh, Schwarz, Lieber: "A biochemically defined system for mammalian nonhomologous DNA end joining." in: Molecular cell, Vol. 16, Issue 5, pp. 701-13, (2004) (PubMed).

Ma, Pannicke, Schwarz, Lieber: "Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination." in: Cell, Vol. 108, Issue 6, pp. 781-94, (2002) (PubMed).

Callebaut, Moshous, Mornon, de Villartay: "Metallo-beta-lactamase fold within nucleic acids processing enzymes: the beta-CASP family." in: Nucleic acids research, Vol. 30, Issue 16, pp. 3592-601, (2002) (PubMed).

Moshous, Callebaut, de Chasseval, Corneo, Cavazzana-Calvo, Le Deist, Tezcan, Sanal, Bertrand, Philippe, Fischer, de Villartay: "Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency." in: Cell, Vol. 105, Issue 2, pp. 177-86, (2001) (PubMed).

Details zu DCLRE1C

Target: DCLRE1C (DNA Cross-Link Repair 1C (DCLRE1C))

Andere Bezeichnung: DCLRE1C (DCLRE1C Produkte)

Synonyme: artemis antikoerper, A-SCID antikoerper, DCLREC1C antikoerper, RS-SCID antikoerper, SCIDA antikoerper, SNM1C antikoerper, hSNM1C antikoerper, Snm1l antikoerper, nuclease antikoerper, 9930121L06Rik antikoerper, AI661365 antikoerper, Art antikoerper, DNA cross-link repair 1C antikoerper, DCLRE1C antikoerper, Dclre1c antikoerper

Hintergrund: DCLRE1C (DNA cross-link repair 1C protein) is required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments. V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends. These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively. This protein exhibits single-strand specific 5'-3' exonuclease activity in isolation and acquires endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC. The latter activity is required specifically for the resolution of closed hairpins prior to the formation of the coding joint. May also be required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by NHEJ.
Synonyms: ARTEMIS, ASCID, SCIDA, SNM1C

Pathways: DNA Reparatur