Der Maus Monoklonal anti-GRK2 Antikörper (Klon 3F8) (ABIN865440) detektiert spezifisch GRK2 in WB, ELISA, IHC und IF.
Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus, Ratte und Affe.
The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.Tissue specificity: Expressed in peripheral blood leukocytes Synonyms: GRK2, BARK1, FLJ16718, BETA-ARK1, ADRBK1