CYP2B6 Antikörper

Produktnummer ABIN2718982

Es sind 3+ Publikationen für dieses Produkt verfügbar. Der Maus Monoklonal anti-CYP2B6 Antikörper wird verwendet zum Nachweis von CYP2B6 in Proben von Human, Maus, Ratte, Hund und Affe. Er wurde validiert für WB, IHC, IF und FACS.

Kurzübersicht für CYP2B6 Antikörper (ABIN2718982)

Target: CYP2B6 (Cytochrome P450, Family 2, Subfamily B, Polypeptide 6 (CYP2B6))

Reaktivität: Human, Maus, Ratte, Hund, Affe

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CYP2B6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Klon: 3D5

Produktdetails anti-CYP2B6 Antikörper

Produktmerkmale: Homo sapiens cytochrome P450, family 2, subfamily B, polypeptide 6 (CYP2B6)

Aufreinigung: Purified from mouse ascites fluids by affinity chromatography

Immunogen: Full length human recombinant protein of human CYP2B6(NP_000758) produced in HEK293T cell.

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: WB 1:500~2000, IHC 1:150, IF 1:100, FLOW 1:100,

Kommentare:

The concentration of the product may vary between diferrent lots.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5-1.0 mg/mL

Buffer: PBS (PH 7.3) containing 1 % BSA, 50 % glycerol and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Referenzen für anti-CYP2B6 Antikörper (ABIN2718982)

Sim, Nam, Lee, Lee, O, Joo, Liu, Han, Ki, Jeong, Lee, Lee: "Selective induction of hepatic cytochrome P450 2B activity by leelamine in vivo, as a potent novel inducer." in: Archives of pharmacal research, Vol. 38, Issue 5, pp. 725-33, (2015) (PubMed).

Chai, Feng, Zhang, Chen, Cheng, He, Yang, He, Wang, Wang, Chen: "Hepatic expression of detoxification enzymes is decreased in human obstructive cholestasis due to gallstone biliary obstruction." in: PLoS ONE, Vol. 10, Issue 3, pp. e0120055, (2015) (PubMed).

Fredman, Li, Dalli, Chiang, Serhan: "Self-limited versus delayed resolution of acute inflammation: temporal regulation of pro-resolving mediators and microRNA." in: Scientific reports, Vol. 2, pp. 639, (2012) (PubMed).

Details zu CYP2B6

Target: CYP2B6 (Cytochrome P450, Family 2, Subfamily B, Polypeptide 6 (CYP2B6))

Andere Bezeichnung: CYP2B6

Hintergrund: This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described, however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q.

Molekulargewicht: 56.1 kDa

Gen-ID: 1555

NCBI Accession: NM_000767

HGNC: 1555