PSMD2 Antikörper

Produktnummer ABIN2729984

Der Maus Monoklonal anti-PSMD2 Antikörper (Klon 1E7) (ABIN2729984) detektiert spezifisch PSMD2 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für PSMD2 Antikörper (ABIN2729984)

Target: PSMD2 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 2 (PSMD2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PSMD2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: 1E7

Produktdetails anti-PSMD2 Antikörper

Produktmerkmale: Homo sapiens proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 (PSMD2)

Aufreinigung: Purified from mouse ascites fluids by affinity chromatography

Immunogen: Full length human recombinant protein of human PSMD2(NP_002799) produced in HEK293T cell.

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: WB 1:2000,

Kommentare:

The concentration of the product may vary between diferrent lots.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5-1.0 mg/mL

Buffer: PBS (PH 7.3) containing 1 % BSA, 50 % glycerol and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Details zu PSMD2

Target: PSMD2 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 2 (PSMD2))

Andere Bezeichnung: PSMD2

Hintergrund: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. In addition to participation in proteasome function, this subunit may also participate in the TNF signalling pathway since it interacts with the tumor necrosis factor type 1 receptor. A pseudogene has been identified on chromosome 1.

Molekulargewicht: 100 kDa

Gen-ID: 5708

NCBI Accession: NM_002808

HGNC: 5708

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Ubiquitin Proteasome Pathway