ZCCHC11 Antikörper (Middle Region)

Produktnummer ABIN786006

Der Kaninchen Polyklonal anti-ZCCHC11 Antikörper (ABIN786006) detektiert spezifisch ZCCHC11 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus, Ratte, Hund, Rind (Kuh), Meerschweinchen, Pferd und Kaninchen.

Kurzübersicht für ZCCHC11 Antikörper (Middle Region) (ABIN786006)

Target: ZCCHC11 (Zinc Finger, CCHC Domain Containing 11 (ZCCHC11))

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Meerschweinchen, Pferd, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ZCCHC11 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-ZCCHC11 Antikörper

Bindungsspezifität: Middle Region

Sequenz: GSAQQQGDQS IRTRQSSECS ESPSYSPQPQ PFPQNSSQSA AITQPSSQPG

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 92%, Human: 100%, Mouse: 92%, Rabbit: 92%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against ZCCHC11. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ZCCHC11

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 1645 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu ZCCHC11

Target: ZCCHC11 (Zinc Finger, CCHC Domain Containing 11 (ZCCHC11))

Andere Bezeichnung: ZCCHC11

Hintergrund: ZCCHC11 is the uridylyltransferase that acts as a suppressor of microRNA (miRNA) biogenesis by specifically mediating the terminal uridylation of some miRNAs. ZCCHC11 catalyzes the 3' uridylation of precursor let-7 (pre-let-7), a miRNA precursor. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cells and is required for ES cells to maintain pluripotency.ZCCHC11 does not bind RNA by itself, recruited to pre-let-7 miRNAs via its interaction with LIN28A and LIN28B. ZCCHC11 also catalyzes the 3' uridylation of miR-26A, a miRNA that represses IL6 transcript, leading to abrogate IL6 transcript repression and promote cytokine expression.ZCCHC11 may also suppress Toll-like receptor-induced NF-kappa-B activity via binding to T2BP. ZCCHC11 does not play a role in replication-dependent histone mRNA degradation.
Alias Symbols: PAPD3, TUT4
Protein Interaction Partner: UBC, MYC, TIFA, CAND1, DCUN1D1, COPS5, CUL1, CUL2, CUL4B, CUL5, ELAVL1,
Protein Size: 1645

Molekulargewicht: 185 kDa

Gen-ID: 23318

NCBI Accession: NM_001009881, NP_001009881

UniProt: Q5TAX3

Pathways: Stem Cell Maintenance