C3AR1 Antikörper (AA 63-8) (FITC)

Produktnummer ABIN782446

Dieser Maus Monoklonal Antikörper detektiert spezifisch C3AR1 in FACS und IHC (fro). Es zeigt Reaktivität gegenüber Proben von Ratte.

Kurzübersicht für C3AR1 Antikörper (AA 63-8) (FITC) (ABIN782446)

Target: C3AR1 (Complement Component 3a Receptor 1 (C3AR1))

Reaktivität: Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser C3AR1 Antikörper ist konjugiert mit FITC

Applikation: Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))

Klon: 74

Produktdetails anti-C3AR1 Antikörper (FITC)

Bindungsspezifität: AA 63-8

Spezifität: This rat C3a receptor antibody detects a recombinant peptide corresponding to amino acids 161-321 of the large extracellular loop structure, which shares 34 % homology with mouse and human. Deduced amino acid sequences of human/rat C3aR is 58.5 % and 90.7 % with rat/mouse.

Aufreinigung: Affinity chromatography on Protein G

Immunogen: RBL-2H3 transfectants expressing rat C3aR Donor: BALB/c Fusion Partner: X63-Ag8.653

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0,1 mg/mL

Buffer: PBS containing 0.02 % sodium azide (NaN3) as preservative and EIA grade BSA was added as a stabilizing protein to bring the total protein concentration to 4-5 mg/mL.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu C3AR1

Target: C3AR1 (Complement Component 3a Receptor 1 (C3AR1))

Hintergrund: C3aR binds to anaphylotoxin C3a which, among other things, is involved in mast cell degranulation and recruitment of immune cells to the site of inflammation. Activation of the complement cascade produces various fragments, including C3a and C5a. C3aR is characterized by seven transmembrane domains including a large extracellular loop which is coupled to a Gi protein. C3aR expression is detected on glial cells, neurons and cells belonging to the mononuclear phagocyte system. C3aR expression was shown to moderately increase after LPS stimulation.Synonyms: AZ3B, C3AR, C3AR1, C3R1, C3a anaphylatoxin chemotactic receptor, C3a-R, HNFAG09

Gen-ID: 84007

NCBI Accession: NP_114449

UniProt: O55197

Pathways: Komplementsystem