E-cadherin Antikörper
Kurzübersicht für E-cadherin Antikörper (ABIN781325)
Target
Alle E-cadherin (CDH1) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Spezifität
- Plasma membrane
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Aufreinigung
- Protein G-Sepharose affinity purified.
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Immunogen
- Recombinant fragment of Human CDH1 (N-terminus).
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Isotyp
- IgG
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Applikationshinweise
- Recommended dilutions. ELISA: 1/5000 - 1/20000. WB: 1/100-1/2000.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Konzentration
- 50µg/50µl
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Buffer
- 0.02% Sodium Azide and 50% glycerol, 1%BSA, PBS, pH7.4.
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- -20 °C
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- E-cadherin (CDH1) (Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1))
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Andere Bezeichnung
- CDH1
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Hintergrund
- This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization.
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Molekulargewicht
- 42kDa
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Pathways
- WNT Signalweg, Sensory Perception of Sound, Cell-Cell Junction Organization, Tube Formation
Target
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