SLC6A4 Antikörper (AA 401-500)

Produktnummer ABIN735983

Es sind 6+ Publikationen für dieses Produkt verfügbar. Der Kaninchen Polyklonal anti-SLC6A4 Antikörper wird verwendet zum Nachweis von SLC6A4 in Proben von Human, Ratte, Maus und Huhn. Er wurde validiert für WB, ELISA, IF (p) und IHC (p).

Kurzübersicht für SLC6A4 Antikörper (AA 401-500) (ABIN735983)

Target: SLC6A4 (Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4))

Reaktivität: Human, Ratte, Maus, Huhn

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SLC6A4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-SLC6A4 Antikörper

Bindungsspezifität: AA 401-500

Kreuzreaktivität: Huhn, Human, Maus, Ratte

Homologie: Dog,Cow,Sheep,Pig,Guinea Pig

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human 5-HTT

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-SLC6A4 Antikörper (ABIN735983)

Yu, Huang, Zhang, Ye, Chi, Zou, Lv, Zheng: "Comparison of 5-hydroxytryptophan signaling pathway characteristics in diarrhea-predominant irritable bowel syndrome and ulcerative colitis." in: World journal of gastroenterology, Vol. 22, Issue 12, pp. 3451-9, (2016) (PubMed).

Wang, Gu, Liu, Bai, Wang: "Fluoxetine protects against methamphetamine‑induced lung inflammation by suppressing oxidative stress through the SERT/p38 MAPK/Nrf2 pathway in rats." in: Molecular medicine reports, Vol. 15, Issue 2, pp. 673-680, (2016) (PubMed).

Wojtal, Cee, Lang, Götze, Frühauf, Geier, Pastor-Anglada, Torres-Torronteras, Martí, Fried, Lutz, Maggiorini, Gassmann, Rogler, Vavricka: "Downregulation of duodenal SLC transporters and activation of proinflammatory signaling constitute the early response to high altitude in humans." in: American journal of physiology. Gastrointestinal and liver physiology, Vol. 307, Issue 7, pp. G673-88, (2014) (PubMed).

Wang, Liu, Wang, Bai, Zhang, Sun, Wang: "Involvement of serotonin mechanism in methamphetamine-induced chronic pulmonary toxicity in rats." in: Human & experimental toxicology, (2013) (PubMed).

Dong, Li, Zheng, Mu, Zhang, Liu: "A representative prescription for emotional disease, Ding-Zhi-Xiao-Wan restores 5-HT system deficit through interfering the synthesis and transshipment in chronic mild stress-induced depressive rats." in: Journal of ethnopharmacology, Vol. 150, Issue 3, pp. 1053-61, (2013) (PubMed).

Bai, Wang, Liu, Wang, Lian, Zhang, Kang, Wang: "4-Chloro-DL-phenylalanine protects against monocrotaline‑induced pulmonary vascular remodeling and lung inflammation." in: International journal of molecular medicine, Vol. 33, Issue 2, pp. 373-82, (2013) (PubMed).

Details zu SLC6A4

Target: SLC6A4 (Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4))

Andere Bezeichnung: SLC6A4/5-HTT

Hintergrund:

Synonyms: HTT, 5HTT, OCD1, SERT, 5-HTT, SERT1, hSERT, 5-HTTLPR, Sodium-dependent serotonin transporter, 5HT transporter, Solute carrier family 6 member 4, SLC6A4

Background: Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.

Gen-ID: 6532

UniProt: P31645