DNAJC3 Antikörper (AA 351-450)

Produktnummer ABIN735548

Es gibt 1 Publikation für dieses Produkt. Der Kaninchen Polyklonal anti-DNAJC3 Antikörper wird verwendet zum Nachweis von DNAJC3 in Proben von Maus und Ratte. Er wurde validiert für ELISA, IF (cc), IF (p), IHC (p) und IHC (fro).

Kurzübersicht für DNAJC3 Antikörper (AA 351-450) (ABIN735548)

Target: DNAJC3 (DnaJ (Hsp40) Homolog, Subfamily C, Member 3 (DNAJC3))

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DNAJC3 Antikörper ist unkonjugiert

Applikation: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-DNAJC3 Antikörper

Bindungsspezifität: AA 351-450

Kreuzreaktivität: Maus, Ratte

Homologie: Human,Dog,Cow,Pig,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human p58ipk/DNAJC3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-DNAJC3 Antikörper (ABIN735548)

Taguchi, Allende, Mizukami, Cook, Gavrilova, Tuymetova, Clarke, Chen, Olivera, Proia: "Sphingosine-1-phosphate Phosphatase 2 Regulates Pancreatic Islet β-Cell Endoplasmic Reticulum Stress and Proliferation." in: The Journal of biological chemistry, Vol. 291, Issue 23, pp. 12029-38, (2016) (PubMed).

Details zu DNAJC3

Target: DNAJC3 (DnaJ (Hsp40) Homolog, Subfamily C, Member 3 (DNAJC3))

Andere Bezeichnung: DNAJC3

Hintergrund:

Synonyms: DNAJC3, Protein Kinase Inhibitor P58, DnaJ homolog subfamily C member 3, HP58, Interferon induced, double stranded RNA activated protein kinase inhibitor, P58, p58 ipk , P58IPK, PRKRI, Protein kinase inhibitor of 58 kDa, Protein kinase inhibitor p58.

Background: DNAJC3 may act as an inhibitor of both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2/PKR to catalyze phosphorylation of the EIF2A. It also functions as a Co-chaperone of HSPA8/HSC70 and is involved in the unfolded protein response (UPR) during ER stress. It has been reported that this protein stimulates the ATPase activity of HSPA8/HSC70.DNAJC3 is also involved in ativiral defense - it is activated in response to infection by influenza virus through the dissociation of DNAJB1. DNAJC3 is widely expressed and can be found at high levels in the testis and pancreas (expression in cell lines is variable).

Gen-ID: 5611

UniProt: Q13217

Pathways: ER-Nucleus Signaling