TRKB Antikörper (pTyr705)

Produktnummer ABIN710861

Der Kaninchen Polyklonal anti-TRKB Antikörper wird verwendet zum Nachweis von TRKB in Proben von Ratte und Maus. Er wurde validiert für WB, IHC (p), IF (cc), IF (p) und IHC (fro).

Kurzübersicht für TRKB Antikörper (pTyr705) (ABIN710861)

Target: TRKB (NTRK2) (Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2))

Reaktivität: Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TRKB Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-TRKB Antikörper

Bindungsspezifität: pTyr705

Kreuzreaktivität: Maus, Ratte

Homologie: Human,Dog,Cow,Pig,Horse,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from rat NTRK2 around the phosphorylation site of Tyr705

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu TRKB

Target: TRKB (NTRK2) (Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2))

Andere Bezeichnung: TrkB

Hintergrund:

Synonyms: TrkB Tyr705, NTRK2Tyr705, NTRK2phospho Y705, TrkB, Tyrosine Receptor Kinase B, Tyrosine kinase,Pyk2, BDNF tropomyosine receptor kinase B, BDNF/NT 3 growth factors receptor, BDNF/NT-3 growth factors receptor, Brain derived neurotrophic factor receptor, GP145 TrkB, GP145-TrkB, GP145-TrkB/GP95-TrkB, GP95 TrkB, Neurotrophic tyrosine kinase receptor type 2, Neurotrophin receptor tyrosine kinase type 2, NTRK 2, Ntrk2, NTRK2_HUMAN, Obesity, hyperphagia, and developmental delay, included, RATTRKB1, Tkrb, Trk B, Trk-B, TRKB, TrkB tyrosine kinase, TRKB1, tyrosine kinase receptor B, Tyrosine receptor kinase B.

Background: The Trk family of nerve growth factor receptors includes Trk A(also referfed to as Trk A gp140),Trk B and Trk C. The prototype member of this gene family, Trk A, encodes a 140 kDa cell surface receptor, gp140, the expression of which is restricted in vivo to neurons of the sensory spinal and cranial gangliaof neurocrest origin. Nerve growth factor (NGF) stimulates tyrosine phosphorylation of Trk gp 140 in neural cell lines and in embryonic dorsal root ganglia. By comparison, BDNF and to a lesser extent, NT-3, but not NGF, can induce tyrosine phophorylayion of Trk B gp 145. The third member of the Trk receptor family, Trk C incodes a 140 kDa protein, Trk C gp140, that is preferentially expressed in brain tissue and primarily functions as a receptor for NT-3.An additional component of the Trk receptor complex, NGFR p175, binds to neurotrophic factors with low affinity but is required for efficient signaling. NGFR p175 accelerates Trk activation and may recruit downstream dffector molecules to the ligand-bound receptor complex.

Gen-ID: 4915

Pathways: RTK Signalweg, Neurotrophin Signalübertragung, cAMP Metabolic Process, Skeletal Muscle Fiber Development, Feeding Behaviour, Dicarboxylic Acid Transport