SYVN1 Antikörper (N-Term)

Produktnummer ABIN650702

Es sind 4+ Publikationen für dieses Produkt verfügbar. Der Kaninchen Polyklonal anti-SYVN1 Antikörper wird verwendet zum Nachweis von SYVN1 in Proben von Human. Er wurde validiert für WB.

Kurzübersicht für SYVN1 Antikörper (N-Term) (ABIN650702)

Target: SYVN1 (Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SYVN1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB15288

Produktdetails anti-SYVN1 Antikörper

Bindungsspezifität: AA 106-138, N-Term

Homologie: M, X

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This HRD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 106-138 amino acids from the N-terminal region of human HRD1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-SYVN1 Antikörper (ABIN650702)

Di, Wang, Han, Fu, Duerfeldt, Blagg, Mu: "Grp94 Protein Delivers γ-Aminobutyric Acid Type A (GABAA) Receptors to Hrd1 Protein-mediated Endoplasmic Reticulum-associated Degradation." in: The Journal of biological chemistry, Vol. 291, Issue 18, pp. 9526-39, (2016) (PubMed).

van den Boomen, Timms, Grice, Stagg, Skødt, Dougan, Nathan, Lehner: "TMEM129 is a Derlin-1 associated ERAD E3 ligase essential for virus-induced degradation of MHC-I." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, Issue 31, pp. 11425-30, (2014) (PubMed).

Wang, Yu, Guo, Zuo, Fisher, Subjeck, Wang: "Enhanced endoplasmic reticulum entry of tumor antigen is crucial for cross-presentation induced by dendritic cell-targeted vaccination." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 191, Issue 12, pp. 6010-21, (2013) (PubMed).

Burr, van den Boomen, Bye, Antrobus, Wiertz, Lehner: "MHC class I molecules are preferentially ubiquitinated on endoplasmic reticulum luminal residues during HRD1 ubiquitin E3 ligase-mediated dislocation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, Issue 35, pp. 14290-5, (2013) (PubMed).

Details zu SYVN1

Target: SYVN1 (Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1))

Andere Bezeichnung: HRD1

Hintergrund: HRD1 encodes a protein involved in endoplasmic reticulum (ER)-associated degradation. The encoded protein removes unfolded proteins, accumulated during ER stress, by retrograde transport to the cytosol from the ER. This protein also uses the ubiquitin-proteasome system for additional degradation of unfolded proteins. This gene and the mitochondrial ribosomal protein L49 gene use in their respective 3' UTRs some of the same genomic sequence.

Molekulargewicht: 67685

NCBI Accession: NP_115807, NP_757385

UniProt: Q86TM6

Pathways: ER-Nucleus Signaling, Negative Regulation of intrinsic apoptotic Signaling