V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (Avian) (ERBB3) Antikörper

Antigen: V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (Avian) (ERBB3)

Synonyme: ERBB3

Wirt: Ziege

Produktnummer: ABIN645836

Produktbeschreibung

Produktmerkmale: Goat Anti-ERBB3 / HER3, with HRP-conjugated secondary antibody

Weitere Bezeichnung: ERBB3 / HER3

Swiss-Prot: NP_001973.2.

Immunogen: Peptide with sequence -HSRLFPKANAQRT, from the C-terminus of the protein sequence according to NP_001973.2. was used as immunogen.

Kreuzreaktivität: Maus, Ratte (Rattus)

Wiederherstellung: Supplied as 100 µg of purified antibody. 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Please avoid freeze-thaw cycles.

Isotyp: IgG  (Passende Sekundärantikörper)

Beschreibung: The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. Full length ErbB-3 is detected at 180 kDa by SDS-PAGE and is overexpressed in human mammary tumors. The ErbB-3 gene also produces several alternative variants, including a secreted form of 85 kDa which negatively regulates heregulin-stimulated ErbB activation. ErbB-3 heterodimerizes with Neu and binds heregulin in order to activate phosphoinositide (PI) 3-kinase. The recruitment and activation of PI 3-kinase occurs via its interaction with phosphorylated YXXM motifs in the carboxy terminus of ErbB-3.

Spezifität: The ErbB3 goat antibody detects protein derived from human, Jurkat cell lysate at various concentrations.

Anwendungen

Bestandteile: HRP-conjugated secondary antibody provided along with this antibody

Lagerung: Store at -20 ° C, if not intended for use within a month, Keep it at 4 ° C and minimize freezing and thawing when use.

Beschränkungen: Nur für Forschungszwecke einsetzbar