Caspase 7 Antikörper (C-Term)

Produktnummer ABIN644997

Der Kaninchen Polyklonal anti-Caspase 7 Antikörper (ABIN644997) detektiert spezifisch Caspase 7 in WB und IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Caspase 7 Antikörper (C-Term) (ABIN644997)

Target: Caspase 7 (CASP7) (Caspase 7, Apoptosis-Related Cysteine Peptidase (CASP7))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Caspase 7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-Caspase 7 Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: Rabbit Anti-Human CASP7 (C-term)

Spezifität: DS-PB-00381 recognizes an epitope within the C-terminal region (CT) of Caspase7, a 35kDa cysteine protease, otherwise known as ICE like Apoptotic Protease 3 (ICELAP3). Caspase7, a member of the ICE/Ced3 subfamily, is an executioner caspase which undergoes proteolytic cleavage of its precursor to form active p12 and p20 subunits. Evidence that activation of Caspase7 occurs during cell death induced by the cytokine death receptors Fas/APO1 and the receptor of tumor necrosis factor (TNFR1), coupled with the fact that granzymeB activated Caspase7 cleaves the nuclear enzyme poly (ADPribose) polymerase (PARP), suggests an important role for Caspase7 in both cytokinemediated and GranzymeB mediated apoptosis pathways.

Kreuzreaktivität: Maus, Ratte (Rattus)

Produktmerkmale: Phosphorylation/Apoptosis/Signal Transduction/Regulation

Aufreinigung: Purified

Immunogen: Antisera to human Caspase-7 (CT) were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Immunohistology - Paraffin, Western Blotting

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: IgG concentration 1.0 mg/ml

Buffer: Phosphate buffered saline

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C

Details zu Caspase 7

Target: Caspase 7 (CASP7) (Caspase 7, Apoptosis-Related Cysteine Peptidase (CASP7))

Andere Bezeichnung: Caspase-7

Pathways: Apoptose, Caspase Kaskade in der Apoptose, Positive Regulation of Endopeptidase Activity