GAPDH Antikörper (C-Term)

Produktnummer ABIN644070

Der Kaninchen Polyklonal anti-GAPDH Antikörper (ABIN644070) detektiert spezifisch GAPDH in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für GAPDH Antikörper (C-Term) (ABIN644070)

Target: GAPDH (Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GAPDH Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-GAPDH Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: Rabbit Anti-Human GAPDH (C-term)

Spezifität: DS-PB-00847 recognizes an epitope within the C-terminal region (CT) of Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), a glycolytic enzyme which plays a key role in energy production, and has also been implicated in numerous cellular processes. GAPDH is a homotetramer molecule consisting of four 36kDa subunits, constitutively expressed in most cells and tissues, and is responsible for the generation of energy during carbohydrate metabolism, catalyzing the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate. The role of GAPDH as a multifunctional protein has emerged from many studies, confirming its involvement in critical nuclear pathways, apoptosis, membrane transport and fusion, DNA replication and repair and phosphotransferase activity. Furthermore, the ability of GAPDH to bind with high affinity to beta-amyloid precursor protein (Alzheimer's disease) and selectively with CAG mutated proteins, including huntingtin (Huntingdon's disease) and the androgen receptor (spinobulbar muscular atrophy), has focused many studies towards the role of GAPDH in the pathogenesis of neurodegenerative diseases (1). Western BlotDS-PB-00847 detects a band of approximately 37kDa in HeLa cell lysates.

Kreuzreaktivität: Maus, Ratte (Rattus)

Aufreinigung: Purified

Immunogen: Antisera to human GAPDH (CT) were raised by repeated immunisation of rabbits with highly purified antigen.Purified IgG prepared by affinity chromatography.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western Blotting

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: IgG concentration 1.0 mg/ml

Buffer: Phosphate buffered saline

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C

Details zu GAPDH

Target: GAPDH (Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH))

Andere Bezeichnung: GAPDH