LAMP2 Antikörper

Produktnummer ABIN638447

Produktdetails anti-LAMP2 Antikörper

Target: LAMP2 (Lysosomal-Associated Membrane Protein 2 (LAMP2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser LAMP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: The mouse monoclonal antibody H4B4 recognizes an extracellular/luminal epitope of CD107b / LAMP-2, an extensively glycosylated 100-120 kDa widely expressed lysosome-associated protein.

Keine Kreuzreaktivität: Maus, Ratte

Kreuzreaktivität (Details): Human

Aufreinigung: Purified by protein-A affinity chromatography.

Reinheit: > 95 % (by SDS-PAGE)

Immunogen: Human PBMC

Klon: H4B4

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Flow cytometry: Intracellular and extracellular staining, recommended dilution: 1-2 μg/mL.
Immunohistochemistry: Recommended dilution: 2-8 μg/mL.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4

Konservierungsmittel: Azide free

Handhabung: Do not freeze.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C. Do not freeze.

Referenzen für anti-LAMP2 Antikörper (ABIN638447)

Thedrez, Harly, Morice, Salot, Bonneville, Scotet: "IL-21-mediated potentiation of antitumor cytolytic and proinflammatory responses of human V gamma 9V delta 2 T cells for adoptive immunotherapy." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 6, pp. 3423-31, (2009) (PubMed).

Meade, Wilson, Holmes, de Wynter, Brett, Straszynski, Ballard, Trapani, McDermott, Cook: "Proteolytic activation of the cytotoxic phenotype during human NK cell development." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 2, pp. 803-13, (2009) (PubMed).

Guia, Cognet, de Beaucoudrey, Tessmer, Jouanguy, Berger, Filipe-Santos, Feinberg, Camcioglu, Levy, Al Jumaah, Al-Hajjar, Stephan, Fieschi, Abel, Brossay, Casanova, Vivier: "A role for interleukin-12/23 in the maturation of human natural killer and CD56+ T cells in vivo." in: Blood, Vol. 111, Issue 10, pp. 5008-16, (2008) (PubMed).

Apte, Baz, Groves, Kelso, Kienzle: "Interferon-gamma and interleukin-4 reciprocally regulate CD8 expression in CD8+ T cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 45, pp. 17475-80, (2008) (PubMed).

Borgne-Sanchez, Dupont, Langonné, Baux, Lecoeur, Chauvier, Lassalle, Déas, Brière, Brabant, Roux, Péchoux, Briand, Hoebeke, Deniaud, Brenner, Rustin, Edelman, Rebouillat, Jacotot: "Targeted Vpr-derived peptides reach mitochondria to induce apoptosis of alphaVbeta3-expressing endothelial cells." in: Cell death and differentiation, Vol. 14, Issue 3, pp. 422-35, (2007) (PubMed).

Kannanganat, Ibegbu, Chennareddi, Robinson, Amara: "Multiple-cytokine-producing antiviral CD4 T cells are functionally superior to single-cytokine-producing cells." in: Journal of virology, Vol. 81, Issue 16, pp. 8468-76, (2007) (PubMed).

Palmer, Fernandez, Bisbing, Peachman, Rao, Barvir, Gunther, Burgess, Kohno, Padmanabhan, Sun: "Restricted replication and lysosomal trafficking of yellow fever 17D vaccine virus in human dendritic cells." in: The Journal of general virology, Vol. 88, Issue Pt 1, pp. 148-56, (2006) (PubMed).

Denzer, van Eijk, Kleijmeer, Jakobson, de Groot, Geuze: "Follicular dendritic cells carry MHC class II-expressing microvesicles at their surface." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 165, Issue 3, pp. 1259-65, (2000) (PubMed).

Details zu LAMP2

Target: LAMP2 (Lysosomal-Associated Membrane Protein 2 (LAMP2))

Andere Bezeichnung: CD107b (LAMP2 Produkte)

Synonyme: CD107b antikoerper, LAMP-2 antikoerper, LAMPB antikoerper, LGP110 antikoerper, Lamp-2 antikoerper, Lamp-2a antikoerper, Lamp-2b antikoerper, Lamp-2c antikoerper, Mac3 antikoerper, cd107b antikoerper, lamp-2 antikoerper, lampb antikoerper, LAMP2 antikoerper, lamp2 antikoerper, DKFZp459J126 antikoerper, LGP-B antikoerper, sb:cb587 antikoerper, wu:fb14a06 antikoerper, zgc:103532 antikoerper, lysosomal associated membrane protein 2 antikoerper, lysosomal-associated membrane protein 2 antikoerper, lysosomal-associated membrane protein 2 S homeolog antikoerper, lysosomal membrane glycoprotein 2 antikoerper, LAMP2 antikoerper, Lamp2 antikoerper, lamp2.S antikoerper, lamp2 antikoerper

Hintergrund: Lysosomal associated membrane protein 2,CD107b (lysosome-associated membrane protein-2, LAMP-2), together with CD107a / LAMP-1, is a major constituent of lysosomal membrane. The LAMP proteins are involved in lysosome biogenesis and are required for fusion of lysosomes with phagosomes, especially CD107b is important regulator in successful phagosomal maturation. CD107b deficiency causes an accumulation of autophagosomes in many tissues leading to cardiomyopathy and myopathy (Danons disease). Immature CD107b is an approximately 45 kDa protein, but after extensive glycosylation the mature glycoprotein has about 100-120 kDa.,LAMP-2, LAMPB

Gen-ID: 3920

UniProt: P13473

Pathways: Autophagie