KCNJ11 Antikörper (Internal Region)

Produktnummer ABIN614945

Der Ziege Polyklonal anti-KCNJ11 Antikörper wird verwendet zum Nachweis von KCNJ11 in Proben von Human, Maus, Ratte und Hund. Er wurde validiert für WB, IHC (p) und EIA.

Kurzübersicht für KCNJ11 Antikörper (Internal Region) (ABIN614945)

Target: KCNJ11 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 11 (KCNJ11))

Reaktivität: Human, Maus, Ratte, Hund

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser KCNJ11 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-KCNJ11 Antikörper

Bindungsspezifität: Internal Region

Sequenz: ERRARFVSKK GNC

Kreuzreaktivität (Details): Species reactivity (expected):Dog, Mouse, RatSpecies reactivity (tested):Human

Aufreinigung: Immunoaffinity chromatography

Immunogen: Synthetic peptide from an internal region of human Kcnj11 Genename: KCNJ11

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline buffer, pH 7.3, 0.5 % BSA, 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Details zu KCNJ11

Target: KCNJ11 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 11 (KCNJ11))

Andere Bezeichnung: KCNJ11

Hintergrund: Kir6.2/Kcnj11, an ATP sensitive inwardly-rectifying potassium channel, was originally isolated from an insulinoma library. Actual conductance requires association with the sulfonylurea receptor. This receptor is inhibited by sulfonylureas and activated by diazoxide. Mutations in the KNCJ11 gene are found in patients with permanent diabetes mellitus of infancy and hyperinsulinemic hypoglycemia. It is thought that this channel couples metabolism to membrane electrical events fibringing about insulin secretion.Synonyms: ATP-sensitive inward rectifier potassium channel 11, IKATP, Inward rectifier K+ channel Kir6.2, KCNJ11, Potassium channel, inwardly rectifying subfamily J member 11

Gen-ID: 9606

UniProt: Q14654

Pathways: Negative Regulation of Hormone Secretion