C-Type Lectin Domain Family 4, Member M (CLEC4M) (Middle Region) Antikörper

Produktnummer ABIN567172

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch C-Type Lectin Domain Family 4, Member M in WB. Es zeigt Reaktivität gegenüber Proben von Human, Schwein und Pferd.

Kurzübersicht für C-Type Lectin Domain Family 4, Member M (CLEC4M) (Middle Region) Antikörper (ABIN567172)

Target: C-Type Lectin Domain Family 4, Member M (CLEC4M)

Reaktivität: Human, Schwein, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails

Bindungsspezifität: Middle Region

Sequenz: CYFMSNSQRN WHDSVTACQE VRAQLVVIKT AEEQNFLQLQ TSRSNRFSWM

Homologie: Horse: 79%, Human: 100%, Pig: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against CLEC4M. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CLEC4M

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 263 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Antigendetails

Target: C-Type Lectin Domain Family 4, Member M (CLEC4M)

Andere Bezeichnung: CLEC4M

Hintergrund: CLEC4M is a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. It is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses, with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity.
Alias Symbols: CD299, LSIGN, CD209L, L-SIGN, DCSIGNR, HP10347, DC-SIGN2, DC-SIGNR, MGC47866, MGC129964, CLEC4M
Protein Interaction Partner: TLR2, MME, CLEC4M, CD209, ICAM3, ITGAM, AP2M1, HCVgp1,
Protein Size: 263

Molekulargewicht: 30 kDa

Gen-ID: 10332

NCBI Accession: NM_001144906, NP_001138378

UniProt: Q9H2X3