ATP6V1B2 Antikörper (Middle Region)

Produktnummer ABIN503926

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch ATP6V1B2 in WB. Es zeigt Reaktivität gegenüber Proben von Human, Maus, Ratte, Zebrafisch (Danio rerio), Rind (Kuh), Hund, Kaninchen, Meerschweinchen, Schwein und Pferd.

Kurzübersicht für ATP6V1B2 Antikörper (Middle Region) (ABIN503926)

Target: ATP6V1B2 (ATPase, H+ Transporting, Lysosomal 56/58kDa, V1 Subunit B2 (ATP6V1B2))

Reaktivität: Human, Maus, Ratte, Zebrafisch (Danio rerio), Rind (Kuh), Hund, Kaninchen, Meerschweinchen, Schwein, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ATP6V1B2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-ATP6V1B2 Antikörper

Bindungsspezifität: Middle Region

Sequenz: NFIAQGPYEN RTVFETLDIG WQLLRIFPKE MLKRIPQSTL SEFYPRDSAK

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 92%

Produktmerkmale: This is a rabbit polyclonal antibody against ATP6V1B2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ATP6V1B2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 511 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu ATP6V1B2

Target: ATP6V1B2 (ATPase, H+ Transporting, Lysosomal 56/58kDa, V1 Subunit B2 (ATP6V1B2))

Andere Bezeichnung: ATP6V1B2

Hintergrund: ATP6V1B2 is a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. ATP6V1B2 is one of two V1 domain B subunit isoforms and is the only B isoform highly expressed in osteoclasts.This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of two V1 domain B subunit isoforms and is the only B isoform highly expressed in osteoclasts. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: ATP6B1B2, ATP6B2, HO57, VATB, VPP3, Vma2
Protein Interaction Partner: TCF4, UBC, PBDC1, GMPPB, GANAB, SWAP70, MSH2, JUP, MSH6, XRCC6, CRMP1, HYOU1, SEC24C, CUL2, SUPT5H, SSRP1, PDE3A, CSDE1, PAN2, FN1, SRXN1, YIF1B, UNK, ZFYVE19, TUBA1C, INTS2, TRMT1, ABCF3, ATP6V1H, CCT8, SSSCA1, TUBB4B, UBA2, USP34, ATP6V1F, ZBED1, ZPR1,
Protein Size: 511

Molekulargewicht: 56 kDa

Gen-ID: 526

NCBI Accession: NM_001693, NP_001684

UniProt: P21281

Pathways: Transition Metal Ion Homeostasis, Proton Transport