HLA-DPA1 Antikörper (Middle Region)

Produktnummer ABIN503137

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch HLA-DPA1 in WB. Es zeigt Reaktivität gegenüber Proben von Human und Schwein.

Kurzübersicht für HLA-DPA1 Antikörper (Middle Region) (ABIN503137)

Target: HLA-DPA1 (Major Histocompatibility Complex, Class II, DP alpha 1 (HLA-DPA1))

Reaktivität: Human, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HLA-DPA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-HLA-DPA1 Antikörper

Bindungsspezifität: Middle Region

Sequenz: EAQEPIQMPE TTETVLCALG LVLGLVGIIV GTVLIIKSLR SGHDPRAQGT

Homologie: Human: 100%, Pig: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against HLA-DPA1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human HLA-DPA1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 260 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu HLA-DPA1

Target: HLA-DPA1 (Major Histocompatibility Complex, Class II, DP alpha 1 (HLA-DPA1))

Andere Bezeichnung: HLA-DPA1

Hintergrund: The specific function of this protein remains unknown.HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: HLA-DP1A, HLADP, HLASB, PLT1, DP(W3), DP(W4)
Protein Interaction Partner: UBC, CD4, HLA-DPB1, CD74,
Protein Size: 260

Molekulargewicht: 26 kDa

Gen-ID: 3113

NCBI Accession: NM_033554, NP_291032

UniProt: P20036

Pathways: T-Zell Rezeptor Signalweg, Cancer Immune Checkpoints, Human Leukocyte Antigen (HLA) in Adaptive Immune Response