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AES Antikörper (N-Term)

AES Reaktivität: Human, Maus WB, IF, EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN499227
  • Target Alle AES Antikörper anzeigen
    AES (Amino-terminal Enhancer of Split (AES))
    Bindungsspezifität
    • 15
    • 11
    • 8
    • 7
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 47
    • 14
    • 13
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    Human, Maus
    Wirt
    • 44
    • 2
    • 1
    Kaninchen
    Klonalität
    • 46
    • 1
    Polyklonal
    Konjugat
    • 23
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser AES Antikörper ist unkonjugiert
    Applikation
    • 29
    • 22
    • 13
    • 13
    • 5
    • 5
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
    Spezifität
    AES antibody was raised against a 16 amino acid peptide from near the amino-terminus of human AES.
    Aufreinigung
    Affinity chromatography purified via peptide column
    Immunogen
    Human AES / Amino-terminal enhancer of split / GRG / ESP1 / TLE5 (N-Terminus) Peptide
    Isotyp
    IgG
    Top Product
    Discover our top product AES Primärantikörper
  • Applikationshinweise
    ELISA. Western Blot: AES antibody can be used for the detection of AES at 2 - 4 μg/mL. Immunocytochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS containing 0.02 % Sodium Azide as preservative
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    AES (Amino-terminal Enhancer of Split (AES))
    Andere Bezeichnung
    AES / ESP1 (AES Produkte)
    Synonyme
    AES-1 antikoerper, AES-2 antikoerper, ESP1 antikoerper, GRG antikoerper, GRG5 antikoerper, TLE5 antikoerper, AL024115 antikoerper, Esp1 antikoerper, Grg antikoerper, Grg-5 antikoerper, Grg5 antikoerper, Tle5 antikoerper, zgc:64216 antikoerper, aes-1 antikoerper, aes-2 antikoerper, esp1 antikoerper, grg antikoerper, grg5 antikoerper, tle5 antikoerper, xgrg-5 antikoerper, AES antikoerper, amino-terminal enhancer of split antikoerper, amino-terminal enhancer of split S homeolog antikoerper, AES antikoerper, Aes antikoerper, aes antikoerper, aes.S antikoerper
    Hintergrund
    Adhesion to extracellular matrix regulates cell survival through both integrin engagement and appropriate cell spreading. Anoikis is the molecular mechanism of apop-tosis induced by integrin detachment (1). Amino-terminal enhancer of split (AES) is a member of the Groucho/ transducin-like enhancer of split (TLE) family of transcriptional regulators, a group of transcriptional co-repressors that play important roles in neurogenesis, segmentation, and sex determination (2,3). AES forms a complex with Bit1 (Bcl-2 inhibitor of transcription 1), a mitochondrial protein that is released into the cytoplasm upon onset of apoptosis (4). It has been suggested that this complex turns off a survival-promoting gene transcription program controlled by the TLE protein family. (4). Interestingly, apoptosis of cells transfected with AES and Bit1 could be inhibited if the cells were allowed to attach to fibronectin through the alpha5beta1 integrin suggesting that the Bit1-AES pathway contributing to anoikis is regulated by integrins, and in particular, the alpha5beta1 integrin (4).Synonyms: AES1, Amino-terminal enhancer of split, GRG protein, Gp130-associated protein GAM
    Gen-ID
    166
    NCBI Accession
    NP_001121
    UniProt
    Q08117
    Pathways
    WNT Signalweg, SARS-CoV-2 Protein Interaktom
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