Apoptotic Chromatin Condensation Inducer 1 (ACIN1) Antikörper

Antigen: Apoptotic Chromatin Condensation Inducer 1 (ACIN1)

Synonyme: ACN, ACINUS, fSAP152, KIAA0670, DKFZp667N107, Acn, Acinus, C79325, acinusL, acinusS, mKIAA0670, 2610036I19Rik, 2610510L13Rik, acinus, acinusb, fi14c05, wu:fe06a10, wu:fi14c05, acinusa, acinusl, wu:fb04g06, wu:fb40f03, wu:fb68h03, wu:fb80f07, wu:fc12e10, ik:tdsubc_2g5, si:zc14a17.12, xx:tdsubc_2g5, acn, MGC69430, MGC132201

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human

Applikation: Enzyme Immunoassay (EIA), Western Blot (WB)

Produktnummer: ABIN499203

Produktbeschreibung

Produktmerkmale: Synonyms: KIAA0670, Apoptotic chromatin condensation inducer in the nucleus

Weitere Bezeichnung: Acinus / ACIN1

Gen-ID: 22985

Swiss-Prot: Q9UKV3

Immunogen: Human Acinus Peptide (ABIN499202)

Kreuzreaktivität: Human

Isotyp: IgG  (Passende Sekundärantikörper)

Beschreibung: Chromatin condensation and nuclear fragmentation (CCNF) is the hallmark of apoptosis. CCNF is triggered by the activation of members of caspase family, caspase activated DNase(CAD/DFF40), and several novel proteins including AIF and CIDE (1). A new inducer ofchromatin condensation was recently identified and designated Acinus (for apoptoticchromatin condensation inducer in the nucleus). Acinus is cleaved by caspase-3 and anadditional unknown protease generating a small active peptide p17, which causeschromatin condensation in vitro when it is added to purified nuclei. Acinus also inducesapoptotic chromatin condensation in cells. Acinus is ubiquitously expressed. Threedifferent spliced forms of Acinus have been identified in human and mouse anddesignated AcinusL, AcinusS and AcinusS (2)

Spezifität: Acinus antibody was raised against a peptide corresponding to amino acids 994 to 1009 ofhuman AcinusL, 267 to 282 of human AcinusS’, or 236 to 251 of human AcinusS, which areidentical to those of mouse Acinus. The selected antigenic sequence is located near theN-terminus of active peptide p17. Species: Human. Others not tested. Add. Information: Blocking peptide available: blocking peptide (ABIN499202)

Synonyme: ACN, ACINUS, fSAP152, KIAA0670, DKFZp667N107, Acn, Acinus, C79325, acinusL, acinusS, mKIAA0670, 2610036I19Rik, 2610510L13Rik, acinus, acinusb, fi14c05, wu:fe06a10, wu:fi14c05, acinusa, acinusl, wu:fb04g06, wu:fb40f03, wu:fb68h03, wu:fb80f07, wu:fc12e10, ik:tdsubc_2g5, si:zc14a17.12, xx:tdsubc_2g5, acn, MGC69430, MGC132201

Anwendungen

Applikationshinweise: ELISA. Western Blot: Acinus antibody can be used for detection of acinus at 0.5 to 1 μg/ml. Anapproximate 220 kDa band can be detected. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Reinigung: Aff - Purified

Buffer: PBS containing 0.02% sodium azide.

Lagerung: Store the antibody undiluted at 2-8°C. Shelf life: one year from despatch.

Forschungsgebiet: Zellzyklus, Apoptose/Nekrose

Beschränkungen: Nur für Forschungszwecke einsetzbar