Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 2 (ACE2) (N-Term) Antikörper

Antigen: Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 2 (ACE2)

Synonyme: ACEH, DKFZp434A014, 2010305L05Rik, ACE2, zgc:92514, MGC127593, DKFZp469K2021, Ace2

Epitope: N-Term

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human

Applikation: Enzyme Immunoassay (EIA), Immunhistochemie (Paraffinschnitte) (IHC (p)), Western Blot (WB)

Produktnummer: ABIN499193

Produktbeschreibung

Produktmerkmale: Synonyms: Angiotensin-converting enzyme 2, ACE-related carboxypeptidase, Angiotensin-convertingenzyme homolog

Weitere Bezeichnung: ACE2

Gen-ID: 59272

Swiss-Prot: Q9BYF1

Immunogen: Human ACE2 (N-Terminus) Peptide (ABIN499192)

Kreuzreaktivität: Human

Isotyp: IgG  (Passende Sekundärantikörper)

Beschreibung: Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, andmyocardial physiology (1-2). In contrast to its homolog ACE, ACE2 expression is restrictedto heart, kidney, and testis. Recently. ACE2 has also been shown to be a functionalreceptor of the SARS coronavirus (3). The normal function of ACE2 is to convert the inactivevasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlikeACE, which converts AngI to AngII. While the role of these vasoactive peptides is not wellunderstood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiaccontractility, indicating its importance in regulating heart function (4).

Spezifität: ACE2 antibody was raised against a synthetic peptide corresponding to amino acids nearthe N-terminus of human ACE2. Anti-ACE2 has no cross response to ACE1. Species: Human. Others not tested. Add. Information: Blocking peptide available: blocking peptide (ABIN499192)

Anwendungen

Applikationshinweise: ELISA. Western Blot: ACE2 antibody can be used for the detection of ACE2 at 0.5 to 2 μg/ml. A 90kDa band can be detected. Immunohistochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Reinigung: Aff - Purified

Buffer: PBS containing 0.02% sodium azide.

Lagerung: Store the antibody undiluted at 2-8°C. Shelf life: one year from despatch.

Forschungsgebiet: Metabolismus, Enzyme, Serum/Plasma Proteine

Beschränkungen: Nur für Forschungszwecke einsetzbar