AATF Antikörper

Produktnummer ABIN499185

Der Kaninchen Polyklonal anti-AATF Antikörper (ABIN499185) detektiert spezifisch AATF in WB, IHC (p) und EIA. Dieser Antikörper reagiert spezifisch mit Proben aus Human und Maus.

Kurzübersicht für AATF Antikörper (ABIN499185)

Target: AATF (Apoptosis Antagonizing Transcription Factor (AATF))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser AATF Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-AATF Antikörper

Spezifität: AATF antibody was raised against a 12 amino acid peptide from near the carboxy terminus of human AATF.

Aufreinigung: Immunoaffinity purified IgG

Immunogen: Human AATF Peptide

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western Blot: AATF antibody can be used for the detection of AATF at 0.5 - 1 μg/mL. Humansmall intestine cell lysate can be used as positive control. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu AATF

Target: AATF (Apoptosis Antagonizing Transcription Factor (AATF))

Andere Bezeichnung: AATF

Hintergrund: AATF (apoptosis antagonizing transcription factor) was initially discovered as an interaction partner of ZIP kinase (ZIPK) (1), a member of death-associated protein (DAP) kinase family of pro-apoptotic serine/threonine kinases (2). AATF is a phosphoprotein containing an acidic region and a putative leucine zipper domain and nuclear localization signal, features which are typical of transcription factors. AATF inhibits the ZIPK-mediated pro-apoptotic pathway and may activate other anti-apoptotic pathways (3). Recently, it has also been shown to protect neural cells against oxidative damage induced by amyloid b-peptide and to inhibit aberrant production of the b-peptide by interacting with Par-4 (prostate apoptosis response-4), another pro-apoptotic leucine zipper protein that is associated with neuronal degeneration in Alzheimer's disease (AD) (4,5), suggesting that AATF may have potential therapeutic applications in both familial and sporadic forms of AD.Synonyms: Apoptosis-antagonizing transcription factor, CHE-1, CHE1, DED, HSPC277, Rb-binding protein Che-1

Gen-ID: 26574

NCBI Accession: NP_036270

UniProt: Q9NY61

Pathways: Neurotrophin Signalübertragung, SARS-CoV-2 Protein Interaktom