KCNMB1 Antikörper

Produktnummer ABIN498565

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch KCNMB1 in IHC (p). Es zeigt Reaktivität gegenüber Proben von Human, Ratte und Maus.

Kurzübersicht für KCNMB1 Antikörper (ABIN498565)

Target: KCNMB1 (Potassium Large Conductance Calcium-Activated Channel, Subfamily M, beta Member 1 (KCNMB1))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KCNMB1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-KCNMB1 Antikörper

Spezifität: This antibody detects endogenous levels of MaxiKbeta protein. (region surrounding Lys119)

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: Affinity chromatography

Reinheit: > 95 % by SDS-PAGE

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu KCNMB1

Target: KCNMB1 (Potassium Large Conductance Calcium-Activated Channel, Subfamily M, beta Member 1 (KCNMB1))

Andere Bezeichnung: KCNMB1

Hintergrund: The KCNMB1 gene, located on chromosome 5q34, contains four exons and encodes the 191 amino-acid protein MaxiKbeta subunit 1 (also designated calcium-activated potassium channel beta subunit, BK channel beta subunit, Slo-beta and KVCAbeta). MaxiKbeta subunit 1 consists of two putative transmembrane domains, an extracellular loop containing three consensus sequences for N-linked glycosylation and four cysteine residues that might form disulfide bridges. MaxiKbeta subunit 1, one of four subunits in the MaxiKbeta family, is expressed predominately in smooth muscle tissue but is also found in brain, liver and lymphatic tissues. MaxiKbeta subunit 1 associates with MaxiKalpha to form a calcium-activated potassium channel (also designated MaxiK and BK channel). MaxiKbeta subunit 1 increases the sensitivity of the MaxiKalpha to calcium and voltage. The MaxiKalpha/beta1 channel is the most sensitive of all Maxi channels to calcium. MaxiKbeta plays an important role in vasoregulation by controlling the sensitivity of MaxiK channels to calcium, which leads to the proper amount of arterial relaxation.Synonyms: BK channel beta-1, Calcium-activated potassium channel subunit beta-1, Charybdotoxin receptor subunit beta-1, K VCAbeta-1, Maxi K channel beta-1, Slo-beta-1, subfamily M beta-1

Molekulargewicht: approx. 30 kDa

Gen-ID: 3779

NCBI Accession: NP_004128

UniProt: Q16558