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Antikörper
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anti-Vitamin D3 Receptor (VDR) Antikörper
Vitamin D3 Receptor (VDR) Antikörper
| Antigen |
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| Synonyme |
NR1I1, Nr1i1, VDR, LOC100008907, LOC100136371 |
| Klonalität |
Polyklonal |
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Wirt
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Reaktivität
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Human (31), Huhn (14), Ratte (Rattus) (12), Maus (11), Schwein (4), Hund (3), Hamster (3), Vogel (2), Rind (Kuh) (2), Amphibien (1), Fisch (1), Frosch (1), Kaninchen (1)
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Applikation
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 Alternativen Immunfluoreszenz (IF), Immunhistochemie (Paraffinschnitte) (IHC (p)), Western Blot (WB)
Western Blot (WB) (32), Gel Shift (GS) (8), Immunhistochemie (Paraffinschnitte) (IHC (p)) (8), Enzyme Immunoassay (EIA) (7), ELISA (5), Immunfluoreszenz (IF) (4), Immunpräzipitation (IP) (4), Immunhistochemie (Gefrierschnitte) (IHC (fro)) (3), Dot Blot (Dot) (2), ELISA (Detektionsantikörper) (2), Elektromobilitäts-Experimente (EMSA) (2), Immunhistochemie (IHC) (2), Chromatin-Immunopräzipitation (ChiP) (1)
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| Produktnummer |
ABIN498217 |
| Menge |
100 µg (1.0 mg/ml) (Varianten) |
| Preis |
320,00 € Zzgl. Versandkosten €20,00 und MWSt
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| Lieferung nach |
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| Verfügbarkeit |
Lieferung in 7 bis 10 Werktagen |
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Produktmerkmale
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Synonyms: VDR, 1, 25-dihydroxyvitamin D3 receptor, Nuclear receptor subfamily 1 group I member 1
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Weitere Bezeichnung
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Vitamin D3 receptor / NR1I1
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Gen-ID
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7421
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Swiss-Prot
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P11473
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Kreuzreaktivität
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Human
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Beschreibung
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The active metabolite of vitamin D modulates the expression of a wide variety of genes in adevelopmentally-specific manner. This secosteroid hormone can up- or downregulate theexpression of genes involved in a diverse array of responses such as proliferation,differentiation and calcium homeostasis. 1,25-(OH)2-vitamin D3 exerts its effects throughinteraction with the vitamin D receptor (VDR), a member of the superfamily ofhormone-activated nuclear receptors. In its ligand-bound state, the VDR formsheterodimers with the 9- cis retinoic acid receptor, RXR, and affects gene expression bybinding specific DNA sequences known as hormone response elements, or HREs. Inaddition to regulating the above-mentioned cellular responses, 1,25-(OH)2-vitamin D3exhibits antiproliferative properties in osteosarcom,a melanom,a colon carcinoma andbreast carcinoma cells.
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Spezifität
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This antibody detects endogenous levels of VDR protein. Species Reactivity: Tested: Human
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Applikationshinweise
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Western blot: 1: 500 - 1: 1000. Immunohistochemistry on paraffin sections: 1: 50 - 1: 200. Immunoflourescence: 1: 50 - 1: 200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
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Konzentration
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1.0 mg/ml
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Reinigung
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Aff - Purified
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Buffer
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Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2
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Lagerung
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Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer. Avoid repeatedfreezing and thawing. Shelf life: one year from despatch.
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Forschungsgebiet
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Vitamine
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Beschränkungen
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Nur für Forschungszwecke einsetzbar
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Alternativen zu Antigen "Vitamin D3 Receptor (VDR)", Typ "Antikörper" finden
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Wirte
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Kaninchen (16), Ratte (12), Maus (9), Ziege (6)
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Reaktivitäten
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Human (31), Huhn (14), Ratte (Rattus) (12), Maus (11), Schwein (4), Hund (3), Hamster (3), Vogel (2), Rind (Kuh) (2), Amphibien (1), Fisch (1), Frosch (1), Kaninchen (1)
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Applikationen
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Western Blot (WB) (32), Gel Shift (GS) (8), Immunhistochemie (Paraffinschnitte) (IHC (p)) (8), Enzyme Immunoassay (EIA) (7), ELISA (5), Immunfluoreszenz (IF) (4), Immunpräzipitation (IP) (4), Immunhistochemie (Gefrierschnitte) (IHC (fro)) (3), Dot Blot (Dot) (2), ELISA (Detektionsantikörper) (2), Elektromobilitäts-Experimente (EMSA) (2), Immunhistochemie (IHC) (2), Chromatin-Immunopräzipitation (ChiP) (1)
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Konjugate
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Biotin (3)
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