RAMP2 Antikörper (AA 111-175)

Produktnummer ABIN488105

Der Kaninchen Polyklonal anti-RAMP2 Antikörper wird verwendet zum Nachweis von RAMP2 in Proben von Human. Er wurde validiert für WB.

Kurzübersicht für RAMP2 Antikörper (AA 111-175) (ABIN488105)

Target: RAMP2 (Receptor (G Protein-Coupled) Activity Modifying Protein 2 (RAMP2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RAMP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-RAMP2 Antikörper

Bindungsspezifität: AA 111-175

Spezifität: Recognizes RAMP2
Cellular Localization: Membrane, Single-pass type I membrane protein.

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Aufreinigung: Antigen-Affinity Chromatography.

Immunogen: Synthetic peptide contain a sequence corresponding to a region within amino acids 111 and 175 of Human RAMP2

Anwendungsinformationen

Applikationshinweise: Western blot: 1/500-1/3000Positive Controls: Molt-4, Raji.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.0 mg/mL

Buffer: 0.1 M Tris, 0.1 M Glycine, 10 % Glycerol ( pH 7) containing 0.01 % Thimerosal as a preservative.

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody undiluted at (in aliquots) at -20 °C.

Details zu RAMP2

Target: RAMP2 (Receptor (G Protein-Coupled) Activity Modifying Protein 2 (RAMP2))

Andere Bezeichnung: RAMP2

Hintergrund: The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called Receptor (calcitonin) Activity Modifying Proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport Calcitonin-Receptor-like Receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface.Synonyms: CRLR activity-modifying protein 2, Calcitonin-receptor-like receptor activity-modifying protein 2, Receptor activity-modifying protein 2

Molekulargewicht: 20 kDa

Gen-ID: 10266, 9606

UniProt: O60895

Pathways: cAMP Metabolic Process, Myometrial Relaxation and Contraction, Cell-Cell Junction Organization, Regulation of G-Protein Coupled Receptor Protein Signaling