Guanine Nucleotide Binding Protein (G Protein), alpha 15 (Gq Class) (GNA15) Antikörper

Antigen: Guanine Nucleotide Binding Protein (G Protein), alpha 15 (Gq Class) (GNA15)

Synonyme: GNA16, G[a]15, Galpha15

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human

Applikation: Western Blot (WB)

Produktnummer: ABIN488048

Produktbeschreibung

Produktmerkmale: Synonyms: G alpha-15, GNA15, GNA16, Guanine nucleotide-binding protein subunit alpha-15

Weitere Bezeichnung: G protein alpha 15

Gen-ID: 2769

Swiss-Prot: P30679

Immunogen: Synthetic peptide surrounding amino acid 356 of Human G Protein Alpha 15

Kreuzreaktivität: Human, Maus, Kaninchen, Ratte (Rattus)

Beschreibung: G Protein alpha 16 (GA16) is the only heterotrimeric G protein with a restricted expressionpattern in hematopoietic cells. Differentiation of promyelocytic cells leads to decreasedexpression of GA16. The G protein is known to couple a large number of G protein-coupledreceptors to PLC-beta and can lead to production of the secondary messengersdiacylglycerol and inositol phosphates. Targeted deletion of GA15, a mouse orthologue ofhuman GA16, causes reduced C5α receptor signaling. GA16 serves as a marker, in additionto CD34, for hematopoietic progenitor cells.

Spezifität: The antibody detects GA15 in samples from Human, Mouse, Rat, and Rabbit origins. It also detects GA16 from samples of Human origin. Species: Human, Mouse, Rat and Rabbit. Others not tested.

Anwendungen

Applikationshinweise: Western blotting (0.5-4 µg/ml). From Researcher's feedback, the antibody can be used in Immunohistochemistry (5-20µg/ml). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Konzentration: 0.5 mg/ml

Reinigung: Aff - Purified

Buffer: PBS (pH 7.2) containing 30% Glycerol, 0.5% BSA and 0.01% Thimerosal aspreservative.

Lagerung: Store the antibody undiluted at -20°C or for long term storage (in aliquots) at -70°C. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Beschränkungen: Nur für Forschungszwecke einsetzbar