ELF3 Antikörper (Middle Region)

Produktnummer ABIN486862

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch ELF3 in WB. Es zeigt Reaktivität gegenüber Proben von Human, Rind (Kuh), Hund, Kaninchen, Pferd und Schwein.

Kurzübersicht für ELF3 Antikörper (Middle Region) (ABIN486862)

Target: ELF3 (E74-Like Factor 3 (Ets Domain Transcription Factor, Epithelial-Specific) (ELF3))

Reaktivität: Human, Rind (Kuh), Hund, Kaninchen, Pferd, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ELF3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-ELF3 Antikörper

Bindungsspezifität: Middle Region

Sequenz: GSCGAGAPSP GSSDVSTAGT GASRSSHSSD SGGSDVDLDP TDGKLFPSDG

Homologie: Cow: 86%, Dog: 79%, Horse: 92%, Human: 100%, Pig: 93%, Rabbit: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against ELF3. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human Elf3

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 371 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu ELF3

Target: ELF3 (E74-Like Factor 3 (Ets Domain Transcription Factor, Epithelial-Specific) (ELF3))

Andere Bezeichnung: Elf3

Hintergrund: ELF3 is a novel, highly tissue-restricted member of the ets transcription factor/oncogene family. ELF3 contains two putative DNA binding domains: an ETS domain, which is unique in that the 5' half shows relatively weak homology to known ets factors, and an A/T hook domain, found in HMG proteins and various other nuclear factors. In contrast to any known ets factors, ELF3 is expressed exclusively in epithelial cells. ELF3 is expected to be a critical regulator of epithelial cell differentiation. ETS factor ELF3 is a transcriptional regulator of angiopoietin-1 gene regulation in the setting of inflammation. ELF3 overexpressed early during human breast tumorigenesis. ELF3 expression confers a transformed and in vitro metastatic phenotype to otherwise normal MCF-12A cells. ELF3 mediates the expression of TGF-beta RII, and the transcriptional inhibition of ets-related transcription factor could be a one of the mechanisms of colonic carcinogenesis. ELF3 is positively and negatively modulated by other interacting proteins including Ku70, Ku86, p300, and CBP.
Alias Symbols: EPR-1, ERT, ESE-1, ESX
Protein Interaction Partner: MED23, XRCC5, RPL6, XRCC6, EP300, CBR3, Jun, MYC, BTRC, UBC, PAK1, TAF9, SUMO2, TBP, EPS15, CREBBP, NFKB1, EGFR, ERBB2, EHF, GANAB, ISG15, TARS, P4HB, KRT82, KRT31, JAK1, EEF1D, DDX3X, CALR, ATIC,
Protein Size: 371

Molekulargewicht: 41 kDa

Gen-ID: 1999

NCBI Accession: NM_004433, NP_004424

UniProt: P78545