GNAI1 Antikörper (Middle Region)

Produktnummer ABIN406409

Der Kaninchen Polyklonal anti-GNAI1 Antikörper wird verwendet zum Nachweis von GNAI1 in Proben von Human, Maus, Ratte, Rind (Kuh), Schwein, Meerschweinchen, Hund, Kaninchen, Zebrafisch (Danio rerio), Pferd, Ziege, Saccharomyces cerevisiae und Schaf. Er wurde validiert für WB.

Kurzübersicht für GNAI1 Antikörper (Middle Region) (ABIN406409)

Target: GNAI1 (Guanine Nucleotide Binding Protein (G Protein), alpha Inhibiting Activity Polypeptide 1 (GNAI1))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Schwein, Meerschweinchen, Hund, Kaninchen, Zebrafisch (Danio rerio), Pferd, Ziege, Saccharomyces cerevisiae, Schaf

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GNAI1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-GNAI1 Antikörper

Bindungsspezifität: Middle Region

Sequenz: YQLNDSAAYY LNDLDRIAQP NYIPTQQDVL RTRVKTTGIV ETHFTFKDLH

Homologie: Cow: 100%, Dog: 100%, Goat: 79%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Sheep: 79%, Yeast: 100%, Zebrafish: 85%

Produktmerkmale: This is a rabbit polyclonal antibody against GNAI1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human GNAI1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 354 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu GNAI1

Target: GNAI1 (Guanine Nucleotide Binding Protein (G Protein), alpha Inhibiting Activity Polypeptide 1 (GNAI1))

Andere Bezeichnung: GNAI1

Hintergrund: Guanine nucleotide-binding proteins (G proteins) form a large family of signal-transducing molecules. They are found as heterotrimers made up of alpha, beta, and gamma subunits. Members of the G protein family have been characterized most extensively on the basis of the alpha subunit, which binds guanine nucleotide, is capable of hydrolyzing GTP, and interacts with specific receptor and effector molecules. The G protein family includes Gs and Gi, the stimulatory and inhibitory GTP-binding regulators of adenylate cyclase, Go, a protein abundant in brain (GNAO1), and transducin-1 (GNAT1) and transducin-2 (GNAT2), proteins involved in phototransduction in retinal rods and cones, respectively.Guanine nucleotide-binding proteins (G proteins) form a large family of signal-transducing molecules. They are found as heterotrimers made up of alpha, beta, and gamma subunits. Members of the G protein family have been characterized most extensively on the basis of the alpha subunit, which binds guanine nucleotide, is capable of hydrolyzing GTP, and interacts with specific receptor and effector molecules. The G protein family includes Gs (MIM 139320) and Gi, the stimulatory and inhibitory GTP-binding regulators of adenylate cyclase, Go, a protein abundant in brain (GNAO1, MIM 139311), and transducin-1 (GNAT1, MIM 139330) and transducin-2 (GNAT2, MIM 139340), proteins involved in phototransduction in retinal rods and cones, respectively (Sullivan et al., 1986 [PubMed 3092218], Bray et al., 1987 [PubMed 3110783]). Suki et al. (1987) [PubMed 2440724] concluded that the human genome contains at least 3 nonallelic genes for alpha-i-type subunits of G protein, see, e.g, GNAI2 (MIM 139360), GNAI3 (MIM 139370), and GNAIH (MIM 139180).[supplied by OMIM]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: Gi
Protein Interaction Partner: GPSM3, RGS17, ESR1, ATP4A, RAD52, SVIL, NUCB1, NCF2, MTNR1B, MTNR1A, NCF1, THAP7, RIC8A, RGS14, IQCB1, UBC, RANGAP1, GPR50, GNB1, GNAI3, GNAI2, GNB4, GNB2, PTH1R, PCK1, Haus1, Cep76, Haus4, Recql4, Trim69, Cbx1, PGR, STRN, KLHL3, ADCY5, RASD1, CRHR1, GPSM
Protein Size: 354

Molekulargewicht: 40 kDa

Gen-ID: 2770

NCBI Accession: NM_002069, NP_002060

UniProt: P63096

Pathways: G-protein mediated Events