FCER2 Antikörper

Produktnummer ABIN376377

Der Ratte Monoklonal anti-FCER2 Antikörper (Klon 2G8) (ABIN376377) detektiert spezifisch FCER2 in FACS, ELISA und IHC (fro). Dieser Antikörper reagiert spezifisch mit Proben aus Maus.

Kurzübersicht für FCER2 Antikörper (ABIN376377)

Target: FCER2 (Fc Fragment of IgE, Low Affinity II, Receptor For (CD23) (FCER2))

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser FCER2 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro))

Klon: 2G8

Produktdetails anti-FCER2 Antikörper

Verwendungszweck: Rat Anti-Mouse CD23-LE/AF

Spezifität: Mouse CD23, Mr 45-49 kDa

Produktmerkmale: Low Endotoxin/Azide Free Anti-Mouse CD23 antibody for use in flow cytometry, ELISA, and immunohistochemistry assays.

Endotoxin-Niveau: Low Endotoxin

Immunogen: FceR isolated from B cell lymphoma cell line M12.4.5

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Phosphate buffered saline, pH 7.4

Konservierungsmittel: Azide free

Handhabung: Each reagent is stable for the period shown on the bottle label if stored as directed.

Lagerung: 4 °C

Informationen zur Lagerung: 2-8°C

Details zu FCER2

Target: FCER2 (Fc Fragment of IgE, Low Affinity II, Receptor For (CD23) (FCER2))

Andere Bezeichnung: CD23

Hintergrund: The CD23 antigen is the low affinity IgE Fc receptor, which is a 49 kDa protein with 38 and 28 kDa fragments. It is expressed on most mature, conventional B cells (but not on peritoneal CD5 + B cells), and can also be found on the surface of T cells, macrophages and platelets. It is distinct from the high affinity IgE receptors found on basophils and mast cells, which mediate allergic reactions. The low affinity receptors are thought to play a role in isotype specific immunoregulation. The regulation of CD23 surface expression appears to be integral with the complex IgE system, which involves interactions of cells, cytokines, antibodies and regulatory factors. CD23 has been described as a membrane bound cytokine, in that the soluble cleavage products of CD23 are themselves able to act as cytokines in vitro.

Gen-ID: 14128

UniProt: P20693

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process