CD8 alpha Antikörper

Produktnummer ABIN375493

Dieser Ratte Monoklonal Antikörper detektiert spezifisch CD8 alpha in FACS, IP, ICC, IHC (fro), BR und Dep. Es zeigt Reaktivität gegenüber Proben von Maus.

Kurzübersicht für CD8 alpha Antikörper (ABIN375493)

Target: CD8 alpha (CD8A) (CD8a Molecule (CD8A))

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser CD8 alpha Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Blocking Reagent (BR), Depletion (Dep)

Klon: 53-6-7

Produktdetails anti-CD8 alpha Antikörper

Verwendungszweck: Rat Anti-Mouse CD8α-LE/AF

Spezifität: Mouse CD8α, Mr 32-34 kDa

Produktmerkmale: Low Endotoxin/Azide Free Anti-Mouse CD8 alpha antibody for use in flow cytometry, immunohistochemistry / immunocytochemistry, immunoprecipitation, depletion, and blocking assays.

Endotoxin-Niveau: Low Endotoxin

Immunogen: Spleen cells or thymocyte membranes

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Phosphate buffered saline, pH 7.4

Konservierungsmittel: Azide free

Handhabung: Each reagent is stable for the period shown on the bottle label if stored as directed.

Lagerung: 4 °C

Informationen zur Lagerung: 2-8°C

Details zu CD8 alpha

Target: CD8 alpha (CD8A) (CD8a Molecule (CD8A))

Andere Bezeichnung: CD8alpha

Hintergrund: In the mouse, CD8 exists in two forms: (i) a CD8 heterodimer composed of an α chain (CD8 α /Lyt-2) and a β chain (CD8 β /Lyt-3), and (ii) a homodimer of two α chains. The heterodimer is found on the surface of essentially all thymocytes and the 'suppressor/cytotoxic' subpopulation of mature T lymphocytes. Subsets of intestinal intraepithelial lymphocytes express CD8 α without CD8 β. It has been suggested that CD8 + β - T cells mature extrathymically, while development of the CD8 α + β + population of T cells is thymus-dependent. CD8 acts as a coreceptor with MHC Class I-restricted T cell receptors in antigen recognition and positive selection of MHC class I-restricted CD8 + T cells

Gen-ID: 12525

UniProt: P01731

Pathways: T-Zell Rezeptor Signalweg