UNC13D Antikörper (C-Term)

Produktnummer ABIN374437

Dieser Ziege Polyklonal Antikörper detektiert spezifisch UNC13D in WB. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für UNC13D Antikörper (C-Term) (ABIN374437)

Target: UNC13D (Unc-13 Homolog D (UNC13D))

Reaktivität: Human

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser UNC13D Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-UNC13D Antikörper

Bindungsspezifität: C-Term

Sequenz: C-KQASQHALRP AP

Spezifität: This antibody recognizes Munc13-4/UNC13D.

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Aufreinigung: Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide.

Immunogen: Peptide from the the C Terminus of the protein sequence according to NP_954712.1.

Anwendungsinformationen

Applikationshinweise: Peptide ELISA: 1/16,000. Western Blot: 1-3 μg/mL. Approx.105 kDa band observed in Human T-lymphocyte and HeLalysates (calculated MW of 125 kDa according to NP_954712.1).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu UNC13D

Target: UNC13D (Unc-13 Homolog D (UNC13D))

Andere Bezeichnung: UNC13D

Hintergrund: Secretion of the contents of cytolytic granules at the immunologic synapse is a highly regulated process essential for lymphocyte cytotoxicity. This process requires the rapid transfer of perforin containing lytic granules to the target cell interface, followed by their docking and fusion with the plasma membrane. Munc 13-4 localises with cytotoxic granules at the immunologic synapse. Munc 13-4 is essential for the priming step of cytolytic granule secretion preceding vesicle membrane fusion. There are two named isoforms.Synonyms: Munc13-4, Protein unc-13 homolog D

Gen-ID: 201294

NCBI Accession: NP_954712

UniProt: Q70J99

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process