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Antikörper
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anti-Jagged 1 (JAG1) (AA 110-125) Antikörper
Jagged 1 (JAG1) (AA 110-125) Antikörper
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| Synonyme |
AGS, AHD, AWS, HJ1, CD339, JAGL1, MGC104644, Htu, Ozz, Ser-1, slalom, Serrate-1, Headturner, JAG1 |
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Epitope
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| Klonalität |
Polyklonal |
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Wirt
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Reaktivität
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Applikation
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 Alternativen Enzyme Immunoassay (EIA), Immunfluoreszenz (IF), Immunhistochemie (Paraffinschnitte) (IHC (p)), Western Blot (WB)
Western Blot (WB) (11), Enzyme Immunoassay (EIA) (9), Immunfluoreszenz (IF) (3), ELISA (2), Durchflusszytometrie (FACS) (2), Immunhistochemie (Gefrierschnitte) (IHC (fro)) (2), Immunhistochemie (Paraffinschnitte) (IHC (p)) (2), Immunpräzipitation (IP) (2), Dot Blot (Dot) (1), ELISA (Detektionsantikörper) (1), Immunhistochemie (IHC) (1), Neutralisierung (Neut) (1)
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| Produktnummer |
ABIN372790 |
| Menge |
50 µg (0.53 mg/ml) (Varianten) |
| Preis |
360,00 € Zzgl. Versandkosten €20,00 und MWSt
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| Lieferung nach |
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| Verfügbarkeit |
Lieferung in 7 bis 10 Werktagen |
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Produktmerkmale
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Synonyms: Jagged-1, hJ1, JAGL1
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Weitere Bezeichnung
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CD339 / JAG1
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Swiss-Prot
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P78504
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Immunogen
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Synthetic peptide corresponding to aa 110-125 of Human Jagged-1 protein.
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Kreuzreaktivität
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Schimpanse, Human, Maus, Ratte (Rattus)
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Isotyp
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IgG (Passende Sekundärantikörper)
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Beschreibung
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Jagged-1 (JAG1) is a cell surface protein which is one of several ligands that activate Notchand related receptors. JAG1 functions in an embryologically important signaling pathwayand has also been shown to play a role in hematopoiesis. JAG1 inhibits proliferation ofcd34+ macrophage progenitor cells and a JAG1 gene abnormality may be an aggravatingfactor in extrahepatic biliary atresia. Activation of NOTCH1 signaling by JAG1 inducesmonocyte-derived dendritic cell maturation in vitro. JAG1 interaction with NOTCH1 on tumorcells dramatically induces proliferation and inhibition of apoptosis in vitro. Eitherhaploinsufficiency for wild-type JAG1 and/or dominant negative effects produced bymutated JAG1 are responsible for the Alagille syndrome.
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Spezifität
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Recognizes Human Jagged-1 (JAG1). Species Reactivity: Tested: Human. Expected from sequence similarity: Chimpanzee, Rat and Mouse (100% homology). Canine(81%) and Xenopus laevis (85%). Add. Information: Predicted Molecular Weight: 134 kDa.
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Applikationshinweise
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ELISA: 1/2500-1/10000. Western Blot: 1/250-1/1000. Detects a band approximately 150kD in size corresponding toJagged-1 in Mouse liver whole cell lysate and a 75kD band in Human brain and kidneylysates. Immunocytochemistry. Immunofluorescence: 1/100-1/500. Immunohistochemistry on Paraffin Sections: 5 µg/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
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Konzentration
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0.53 mg/ml
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Reinigung
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Aff - Purified
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Buffer
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PBS containing 0.01% Sodium Azide as preservative.
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Lagerung
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Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
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Beschränkungen
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Nur für Forschungszwecke einsetzbar
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Alternativen zu Antigen "Jagged 1 (JAG1)", Typ "Antikörper" finden
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Wirte
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Kaninchen (7), Maus (5), Ziege (2)
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Reaktivitäten
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Human (13), Maus (4), Ratte (Rattus) (4), Schimpanse (1)
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Applikationen
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Western Blot (WB) (11), Enzyme Immunoassay (EIA) (9), Immunfluoreszenz (IF) (3), ELISA (2), Durchflusszytometrie (FACS) (2), Immunhistochemie (Gefrierschnitte) (IHC (fro)) (2), Immunhistochemie (Paraffinschnitte) (IHC (p)) (2), Immunpräzipitation (IP) (2), Dot Blot (Dot) (1), ELISA (Detektionsantikörper) (1), Immunhistochemie (IHC) (1), Neutralisierung (Neut) (1)
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Epitope
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AA 110-125 (1), C-Term (1)
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