GRP78 Antikörper (C-Term)

Produktnummer ABIN363672

Der Kaninchen Polyklonal anti-GRP78 Antikörper (ABIN363672) detektiert spezifisch GRP78 in WB, ICC und IF. Dieser Antikörper reagiert spezifisch mit Proben aus Maus und Ratte.

Kurzübersicht für GRP78 Antikörper (C-Term) (ABIN363672)

Target: GRP78 (HSPA5) (Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5))

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GRP78 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

Produktdetails anti-GRP78 Antikörper

Bindungsspezifität: AA 600-654, C-Term

Spezifität: Reacts with rat and mouse 78 kDa GRP-78 protein

Kreuzreaktivität (Details): Weakly cross reacts with human GRP-78.

Aufreinigung: Antigen affinity purified

Immunogen: Synthetic peptide derived from C-term domain of the rat Grp78 protein. Within residues 600-654.

Anwendungsinformationen

Applikationshinweise:

Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only:
WB0.5 μg/mL ICC/IF1:50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.05 mg/mL

Buffer: PBS, glycerol 30 % , Sodium azide 0.1 %

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Short term storage at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt.

Haltbarkeit: 6 months

Details zu GRP78

Target: GRP78 (HSPA5) (Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5))

Andere Bezeichnung: 78 kDa Glucose-Regulated Protein (GRP-78)

Hintergrund: Categorized as stress response proteins, BiPs play an important role in folding and assembly of nascent proteins and in scavenging of misfolded proteins in the endoplasmic reticulum lumen. Translation of BiP is directed by an internal ribosomal entry site (IRES) in the 5- nontranslated region of BiP mRNA. BiP IRES activity increases when cells are heat-stressed. GRP78 is also important in maintenance of cell homeostasis and the prevention of apoptosis. Levels of GRP78 protein are reduced in brains of Alzheimer's disease patients.

Gen-ID: 25617

Pathways: Thyroid Hormone Synthesis, ER-Nucleus Signaling