TYK2 Antikörper (pTyr1054)

Produktnummer ABIN362143

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch TYK2 in WB. Es zeigt Reaktivität gegenüber Proben von Human und Maus.

Kurzübersicht für TYK2 Antikörper (pTyr1054) (ABIN362143)

Target: TYK2 (Tyrosine Kinase 2 (TYK2))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TYK2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-TYK2 Antikörper

Bindungsspezifität: pTyr1054

Spezifität: The antibody detects endogenous level of TYK2 only when phosphorylated at tyrosine 1054.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removedby chromatography using non-phosphopeptide corresponding to the phosphorylation site.

Immunogen: Peptide sequence around phosphorylation site of pTyr1054 (H-E-Y (p) -Y-R) derived from Human TYK2. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blotting: 1:500-1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Details zu TYK2

Target: TYK2 (Tyrosine Kinase 2 (TYK2))

Andere Bezeichnung: TYK2

Hintergrund: TYK2 encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin

Molekulargewicht: 140 kDa

NCBI Accession: NP_003322

UniProt: P29597

Pathways: JAK-STAT Signalweg, Hepatitis C