Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5) Antikörper

Antigen: Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5)

Synonyme: BIP, MIF2, GRP78, FLJ26106, HSPA5, DKFZp459C013, BiP, GRP-78, BiP/grp78, hspa5, MGC52648

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human, Maus, Meerschweinchen, Rind (Kuh), Fungus (Cryphonectria parasitica), Hamster, Affe, Kaninchen, Xenopus laevis

Applikation: Western Blot (WB)

Produktnummer: ABIN361825

Produktbeschreibung

Produktmerkmale: Detects a protein with a mass of ~78kDa corresponding to Grp78.

Weitere Bezeichnung: GRP78

Gen-ID: NP_005338.1, 3309

Immunogen: Rat GRP78 (Bip) sythetic peptide conjugated to KLH

Format: Liquid

Beschreibung: GRP78 is a ubiquitously expressed, 78-kDa glucose regulated protein, and is commonly referred to as an immunoglobin chain binding protein (BiP). The BiP proteins are categorized as stress response proteins because they play an important role in the proper folding and assembly of nascent protein and in the scavenging of misfolded proteins in the endoplasmic reticulum lumen. Translation of BiP is directed by an internal ribosomal entry site (IRES) in the 5' nontranslated region of the BiP mRNA. BiP IRES activity increases when cells are heat stressed (1). GRP78 is also critical for maintenance of cell homeostasis and the prevention of apoptosis (2). Luo et al. have provided findings that suggest GRP78 is essential for embryonic cell growth and pluripotent cell survival (3). In terms of diseases, GRP78 has been shown to be a reliable biomarker of hypoglycemia, to serve a neuroprotective function in neurons exposed to glutamate and oxidative stress (4), and its protein levels are reduced in the brains of Alzheimer’s patients (5). Also, the induction of the GRP78 protein that results in severe glucose and oxygen deprivation could possible lead to drug resistance to anti-tumor drugs (6, 7).
Synonyms: BIP, Grp78, HspA5, MIF2, immunoglobulin heavy chain binding protein

Spezifität: Detects a protein with a mass of ~78 kDa corresponding to Grp78 Species Cross-Reactivity Human, Mouse, Rat, Cow, Fungus (Cryphonectria parasitica), Hamster, Monkey, Rabbit, Xenopus

Anwendungen

Applikationshinweise: Working dilution Dilution of 1:2000 for WB using ECL.

Reinigung: Antiserum

Lagerung: -20 °C

Storage Shipping Temp Max: Blue Ice or 4 °C

Forschungsgebiet: Hitzeschockproteine

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

Grp78 (bip), rat tissue Mix, polyclonal

Grp78, rat tissues