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LAMP1 Antikörper

LAMP1 Reaktivität: Ratte WB, IF, IP, ICC Wirt: Maus Monoclonal Ly1C6 unconjugated
Produktnummer ABIN361796
  • Target Alle LAMP1 Antikörper anzeigen
    LAMP1 (Lysosomal-Associated Membrane Protein 1 (LAMP1))
    Reaktivität
    • 106
    • 66
    • 37
    • 27
    • 8
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Ratte
    Wirt
    • 67
    • 56
    • 25
    • 1
    Maus
    Klonalität
    • 101
    • 48
    Monoklonal
    Konjugat
    • 53
    • 15
    • 15
    • 12
    • 9
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser LAMP1 Antikörper ist unkonjugiert
    Applikation
    • 93
    • 75
    • 41
    • 34
    • 26
    • 25
    • 25
    • 16
    • 15
    • 13
    • 13
    • 7
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Immunocytochemistry (ICC)
    Spezifität
    Detects ~120 kDa.
    Kreuzreaktivität
    Hamster, Human, Maus, Ratte
    Aufreinigung
    Protein G Purified
    Immunogen
    Rat liver lysosomal membrane preparations
    Klon
    Ly1C6
    Isotyp
    IgG1
    Top Product
    Discover our top product LAMP1 Primärantikörper
  • Applikationshinweise
    • WB (1:1000)
    • ICC/IF (1:1000)
    • optimal dilutions for assays should be determined by the user.
    Kommentare

    1 μg/ml was sufficient for detection of LAMP1 in rat liver miscrosome by ECL immunoblot analysis.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    -20°C
  • Harada, Hiasa: "Immunological identification of vesicular nucleotide transporter in intestinal L cells." in: Biological & pharmaceutical bulletin, Vol. 37, Issue 7, pp. 1090-5, (2014) (PubMed).

    Hiasa, Togawa, Miyaji, Omote, Yamamoto, Moriyama: "Essential role of vesicular nucleotide transporter in vesicular storage and release of nucleotides in platelets." in: Physiological reports, Vol. 2, Issue 6, (2014) (PubMed).

  • Target
    LAMP1 (Lysosomal-Associated Membrane Protein 1 (LAMP1))
    Andere Bezeichnung
    LAMP1 (LAMP1 Produkte)
    Synonyme
    CD107a antikoerper, LAMPA antikoerper, LGP120 antikoerper, AI196048 antikoerper, Lamp-1 antikoerper, LEP100 antikoerper, LAMP-1 antikoerper, LGP-A antikoerper, Lgpa antikoerper, Lysosome-associated membrane protein 1 antikoerper, cd107a antikoerper, lamp-1 antikoerper, lamp1 antikoerper, lampa antikoerper, lgp120 antikoerper, rexp76 antikoerper, lysosomal associated membrane protein 1 antikoerper, lysosomal-associated membrane protein 1 antikoerper, lysosomal-associated membrane protein 1 L homeolog antikoerper, LAMP1 antikoerper, Lamp1 antikoerper, lamp1.L antikoerper
    Hintergrund
    Lysosme associated membrane proteins, or LAMP1 and LAMP2, are major constituents of the lysosomal membrane. The two have closely related structures, with 37 % sequence homology (2). They are both transmembrane glycoproteins that are localized primarily in lysosomes and late endosomes. Newly synthesized molecules are mostly transported from the trans-Golgi network directly to endosomes and then to lysosomes. A second pathway involves the lamps being delivered from the Golgi to the cell surface, and then along the endocytic pathway to the lysosomes. A minor pathway involves transport via the plasma membrane (3). Upon stimulation, a rapid translocation of intracellular LAMPs to the cell membrane is dependent on a carboxylterminal tyrosine ba based motif (YXXI) (1). If there is a disturbance in this spacing, lysosome localization of LAMP1 is abolished and the mutant protein then cycles between the membrane and the endosome (3). This stimulation has also been shown to have an associated release of histamine, leukotriene C (4) and prostaglandin D (2), which shows that LAMP-1 and LAMP-2 are activation markers for normal mast cells (1). They have also been linked to the inflammatory response in that they promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, and therefore possibly the adhesion of PBMC to the site of inflammation (4).
    Gen-ID
    25328
    NCBI Accession
    NP_036989
    UniProt
    P14562
    Pathways
    Autophagie
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