Transient Receptor Potential Cation Channel, Subfamily V, Member 3 (TRPV3) Antikörper

Antigen: Transient Receptor Potential Cation Channel, Subfamily V, Member 3 (TRPV3)

Synonyme: VRL3, Nh, AI644701, MGC124324, MGC124325, 1110036I10Rik, TRPV3, MGC159979

Klonalität: Monoklonal (S15-4)

Wirt: Maus

Reaktivität: Human, Maus, Ratte (Rattus)

Applikation: Western Blot (WB), Immunzytochemie (ICC), Immunpräzipitation (IP)

Produktnummer: ABIN361778

Produktbeschreibung

Produktmerkmale: Detects ~70kDa

Weitere Bezeichnung: TrpV3

Gen-ID: 497948

Immunogen: Synthetic peptdie amino acids 458-474 (C-terminus) of rat TrpV3, accession number NP_001020928

Format: Liquid

Isotyp: IgG2a  (Passende Sekundärantikörper)

Klon: S15-4

Beschreibung: The TRPV3 protein belongs to a family of nonselective cation channels that function in a variety of processes, including temperature sensation and vasoregulation. The thermosensitive members of this family are expressed in subsets of sensory neurons that terminate in the skin, and are activated at distinct physiological temperatures. This channel is activated at temperatures between 22 and 40 degrees C. The gene lies in close proximity to another family member (TRPV1) gene on chromosome 17, and the two encoded proteins are thought to associate with each other to form heteromeric channels .
Synonyms: transient receptor potential cation channel subfamily V member 3, VRL3

Spezifität: ~70kDa. Species cross-reactivity: Human, Mouse, Rat.

Sensitivität: 1 µg/mL of SMC-319 was sufficient for detection of TrpV3 in 10µg of COS-1 cell lysate transiently transfected with TrpV3 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Anwendungen

Applikationshinweise: 1-10ug/mL (WB), 0.1-1.0ug/mL (Perox) (IHC/ICC), 1.0-10ug/mL (IF)

Konzentration: 1 mg/mL

Reinigung: Protein G Purified

Buffer: PBS pH7.4, 50% glycerol

Lagerung: -20 °C

Storage Shipping Temp Max: Blue Ice or 4 °C

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

TrpV3 (S15-4), Human Cell line mix

TrpV3 (S15-4), Human Hippocampus

Publikationen

Publikationen: Xiao, Tang, Wang et al.: "Calcium plays a central role in the sensitization of TRPV3 channel to repetitive stimulations." in: The Journal of biological chemistry, Vol. 283, Issue 10, pp. 6162-74, 2008 (PubMed).

Masamoto, Kawabata, Fushiki: "Intragastric administration of TRPV1, TRPV3, TRPM8, and TRPA1 agonists modulates autonomic thermoregulation in different manners in mice." in: Bioscience, biotechnology, and biochemistry, Vol. 73, Issue 5, pp. 1021-7, 2009 (PubMed).