STXBP1 Antikörper (pSer515)

Produktnummer ABIN318802

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch STXBP1 in WB. Es zeigt Reaktivität gegenüber Proben von Human, Maus, Ratte, Affe, Rind (Kuh), Hund, Huhn und Xenopus laevis.

Kurzübersicht für STXBP1 Antikörper (pSer515) (ABIN318802)

Target: STXBP1 (Syntaxin Binding Protein 1 (STXBP1))

Reaktivität: Human, Maus, Ratte, Affe, Rind (Kuh), Hund, Huhn, Xenopus laevis

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser STXBP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-STXBP1 Antikörper

Bindungsspezifität: pSer515

Spezifität: This antibody recognises Munc-18 phosphorylated at serine 515.

Aufreinigung: Purified

Immunogen: Phosphopeptide corresponding to amino acid sequence surrounding phosphorylated Ser515 of Munc-18.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western Blot: 1: 1000, detects a band/s of approximately 65 kDa in rat cortex cell lysates.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 10 mM Hepes pH 7.5 containing 0.09 % Sodium Azide (NaN3), 50 % Glycerol and 0.01 % Bovine Serum Albumin

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu STXBP1

Target: STXBP1 (Syntaxin Binding Protein 1 (STXBP1))

Andere Bezeichnung: STXBP1 / UNC18A

Hintergrund: Munc-18 is a 67 kDa member of the STXBP/UNC-18/SEC1 family. It is neural specific, expressed in the brain, spinal cord and at very high levels in axons. Munc-18 is crucial to calcium-dependent neurotransmitter release, facilitating synaptic vesicle docking and fusion. It inhibits the formation of soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor (SNARE) complex by binding syntaxin 1 preventing the other components (synaptobrevin and synaptosomal associated protein of 25 kDa (SNAP-25)) from binding. The function of Munc-18 is regulated by the phosphorylation of serine 515 by protein kinase C. Munc-18 is also involved in the onset of female puberty through its regulation of glutamate release.Synonyms: N-Sec1, Syntaxin-binding protein 1, Unc-18 homolog, Unc-18-1, Unc-18A

Gen-ID: 25558

NCBI Accession: NP_037170

UniProt: P61765

Pathways: Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport