SLC16A3 Antikörper

Produktnummer ABIN317918

Der Kaninchen Polyklonal anti-SLC16A3 Antikörper wird verwendet zum Nachweis von SLC16A3 in Proben von Human, Ratte und Maus. Er wurde validiert für WB.

Kurzübersicht für SLC16A3 Antikörper (ABIN317918)

Target: SLC16A3 (Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 3 (SLC16A3))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SLC16A3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-SLC16A3 Antikörper

Spezifität: This antibody detects endogenous levels of MCT4 protein.(region surrounding Phe265)

Aufreinigung: Affinity Chromatography using epitope-specific immunogen.

Anwendungsinformationen

Applikationshinweise: ELISA: 1/40000-1/60000. Western Blot: 1/500-1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2 with 0.05 % Sodium Azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu SLC16A3

Target: SLC16A3 (Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 3 (SLC16A3))

Andere Bezeichnung: SLC16A3

Hintergrund: Monocarboxylates, such as lactate and pyruvate, play an integral role in cellular metabolism. Lactic acid is produced in large quantities as a result of glycolysis, which provides the majority of ATP to cells under normal physiological conditions. However, accumulation of lactic acid leads to a decrease in intracellular pH and cessation of glycolysis. In order for glycolysis to continue at a high rate, lactic acid must be transported out of the cell. This transport process is carried out by a family of monocarboxylate transporters (MCTs),which function as proton symports and are stereoselective for L-lactate.The MCT family consists of at least eight members, MCT1-8, which contain between 10-12 transmembrane-helical (TM) domains, with the amino and carboxy termini located in the cytoplasm. MCT1 is widely expressed and is the major form of MCTs in tumor cells and erythrocytes. MCT2 is highly expressed in liver and testis, while MCT3 and MCT4 are predominantly expressed in skeletal muscle.Synonyms: MCT 3, MCT 4, MCT3, MCT4, Monocarboxylate transporter 3, Monocarboxylate transporter 4, Solute carrier family 16 member 3

Molekulargewicht: approx. 49 kDa

Gen-ID: 9123

NCBI Accession: NP_001035887

UniProt: O15427

Pathways: Warburg Effekt